4-cyano-5,6-diphenylpyridazine-3 (2H)-thione | 112450-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-cyano-5,6-diphenylpyridazine-3 (2H)-thione
• 英文别名: 4-cyano-4,5-diphenylpyridazine-3(2H)-thione；4-cyano-5,6-diphenyl-3(2H)-pyridazinethione；4-cyano-5,6-diphenylpyridazine-3(2H)-thione；4-cyano-5,6-diphenylpyridazin-3(2H)-thione；4-cyano-5,6-diphenylpyridazine-3(2H)thione；5,6-diphenyl-4-cyanopyridazine-3(2H)thione；3,4-diphenyl-6-sulfanylidene-1H-pyridazine-5-carbonitrile
• CAS: 112450-34-7
• 化学式: C₁₇H₁₁N₃S
• 分子量: 289.36
• InChiKey: MEKUCDLQIOYTBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-cyano-5,6-diphenylpyridazine-3 (2H)-thione 在 氢氧化钾 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 30.17h， 生成 2-mercapto-8,9-diphenylpyrimido<4',5':4,5>thieno<2,3-c>pyridazin-4(3H)-one
  参考文献：
  名称：

  Deeb, Ali; Essawy, Abdel Naby; Yasine, Fathy, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1991, vol. 46, # 6, p. 835 - 837

  摘要：

  DOI：
• 作为产物：
  描述：

  3-chloro-5,6-diphenylpyridazine-4-carbonitrile 在 sodium hydrogensulfide 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以92%的产率得到4-cyano-5,6-diphenylpyridazine-3 (2H)-thione
  参考文献：
  名称：

  Synthesis of pyrimido[4′,5′:4,5]thieno[2,3-c]-pyridazine derivatives

  摘要：

  Convenient syntheses of 3,4-diphenyl-8-oxo-6-substituted-5,6,7,8-tetrahydropyrimido[4',5:4,5]thieno[2,3-c]pyridazines (4a-g), 3,4-diphenyl-8-oxo-6-substituted-7,8-dihydropyrimido [4',5':4,5]thieno [2,3-c]pyridazines (5a-g), 8-chloro-3,4-diphenyl-6-substituted-pyrimido[4',5':4,5] thieno [2,3-c]pyridazines (6a-g), and 3,4,6-triphenyl-8-substituted-pyrimido[4',5',4,5]thieno[2,3-c]pyridazines (7a-f) from 4-cyano-5,6-diphenylpyridazine-3(2H)-thione (1) via 5-amino-3,4-diphenylthieno [2,3-c] pyridazine-6-carboxamide (3) are reported.

  DOI：

  10.1007/bf00807079

文献信息

• Thieno[2,3-c]pyridazine Derivatives: Synthesis and Antimicrobial Activity
  作者：Fatma El-Mariah

  DOI：10.1080/10426500802014443

  日期：2008.10.7

  Thieno[2,3-c]pyridazine 2 was selected as the starting material for the synthesis of some novel 5-arylidene amino and 5-thiazolidine derivatives. The structures of the synthesized compounds were elucidated by elemental analyses and spectral data. The antimicrobial and antifungal activities of the newly synthesized products were measured against some microorganisms.

  选择噻吩并[2,3-c]哒嗪2作为合成一些新型5-亚芳基氨基和5-噻唑烷衍生物的原料。通过元素分析和光谱数据阐明了合成化合物的结构。测量了新合成产品对一些微生物的抗微生物和抗真菌活性。
• Synthesis, Reactions and Antimicrobial Activity of Thieno[2,3-<i>c</i>]pyridazine Derivatives
  作者：Fatma El Mariah

  DOI：10.3184/030823409x12508790019612

  日期：2009.10

  The reaction of N1-(un)substituted 4-aminosulfonamide with 6-chloropyridothienopyridazine (5) and 8-chloro-pyrimidothienopyridazine (14) gave 6-substituted aminopyridothienopyridazine (9) and 8-substituted amino-pyrimidothienopyridazine (16) respectively. All of the derivatives have been characterised by analytical and spectroscopic studies and also tested for their in vitro antibacterial and antifungal

  N1-(未)取代的4-氨基磺酰胺与6-氯吡啶并噻吩并哒嗪(5)和8-氯-嘧啶噻吩并哒嗪(14)的反应分别得到6-取代的氨基吡啶并噻吩并哒嗪(9)和8-取代的氨基-嘧啶噻吩并哒嗪(16)。所有衍生物都通过分析和光谱研究进行了表征，并且还测试了它们对多种微生物的体外抗菌和抗真菌活性。
• Pyridazine Derivatives and Related Compounds, Part 28. Pyridazinesulfonamides: Synthesis and Antimicrobial Activity
  作者：Fatma El-Mariah、Ekhlass Nassar、Mona Hosny、Ali Deeb

  DOI：10.1080/10426500802080246

  日期：2008.12.23

  3 gave the 3-substituted aminopyridazines 4 . Also In addition, pyridazine-3-sulfonamides 7 were prepared from the reaction of pyridazine-3-sulfonylchloride 6 with different amines. All of these derivatives have been characterized by analytical and spectroscopic studies, and also were tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

  3-氯哒嗪 1 与 N –(未)取代的 4-氨基磺酰胺 3 反应得到 3-取代的氨基哒嗪 4 。此外，哒嗪-3-磺酰胺7是由哒嗪-3-磺酰氯6与不同的胺反应制备的。所有这些衍生物都通过分析和光谱研究进行了表征，并且还测试了它们对多种微生物的体外抗菌和抗真菌活性。
• The first synthesis of furo[2,3- c ]pyridazin-4(1 H )-one derivatives
  作者：Ádám Andor Kelemen、Balázs Péter Szabó、Péter Kovács、György Miklós Keserű

  DOI：10.1016/j.tetlet.2015.11.068

  日期：2016.1

  We report a five step method for the synthesis of furo[2,3-c]pyridazin-4(1H)-one derivatives representing a novel heteroaromatic ring-system. The first synthesis of 3-carboxylic and methyl-3-carboxylate derivatives of the 1-phenyl and 1-(p-methoxyphenyl) compounds are reported.

  我们报告了代表新杂芳环系统的呋喃[2,3 - c ]哒嗪-4（1 H）-one衍生物的五步合成方法。报道了第一合成的1-苯基和1-（对甲氧基苯基）化合物的3-羧酸和甲基-3-羧酸酯衍生物。
• Synthesis of Some New Pyrimidothienopyridazines and Related Heterocycles
  作者：Sh. M. Radwan、A. M. Kamal El-Dean、E. A. Bakhite

  DOI：10.1002/jccs.200500046

  日期：2005.4

  4–6. Also, the reactions of 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide with heterocyclic aldehydes and/or cycloalkanones were carried out and their products were identified. Moreover, some novel pyridazinothienopyrimidobenzimidazoles 14–17 were synthesized.

  5-氨基-3,4-二苯基噻吩并[2,3-c]哒嗪-6-甲腈2a与丙二胺反应得到四氢嘧啶衍生物3。后一种化合物(3)经过一定的环缩合反应生成嘧啶并噻吩并哒嗪4-6。此外，还进行了5-氨基-3,4-二苯基噻吩并[2,3-c]哒嗪-6-甲酰胺与杂环醛和/或环烷酮的反应并鉴定了它们的产物。此外，合成了一些新的哒嗪并噻吩并嘧啶并苯并咪唑14-17。