Succinic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester 2,5-dioxo-pyrrolidin-1-yl ester | 96328-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Succinic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester 2,5-dioxo-pyrrolidin-1-yl ester
• CAS: 96328-27-7
• 化学式: C₁₆H₁₈N₆O₈
• 分子量: 422.354
• InChiKey: SJOJNBPASOIISS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.39
• 重原子数：
  30.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  188.8
• 氢给体数：
  2.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  3-(N,N-dioctadecylamino)propylamine 、 Succinic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester 2,5-dioxo-pyrrolidin-1-yl ester 生成 N-(3-Dioctadecylamino-propyl)-succinamic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester
  参考文献：
  名称：

  Nucleolipids as Potential Organogelators

  摘要：

  Four different series of nucleolipids or bola-nuclcolipids were synthesized or re-synthesized. Most of the compounds were studied with respect to their gelation properties toward either water or aromatic, hetero-aromatic, and aliphatic hydrocarbons. Bola-nucteolipids 6 and 7 do not gelate any solvent tested, neither as sole additive nor by adding up to 10 wt % of a 1:1 mixture. The nucleolipid 22 carrying the antiviral acyclovir as a head group proved to be a potent organogelator for aromatic hydrocarbons such as toluene, but not for hetarenes, aliphatic hydrocarbons or water. The mono-tailed nucleolipid 24 exhibits excellent organogelator Properties for both aromatic and aliphatic hydrocarbons. These were studied as a function of concentration and temperature.

  DOI：

  10.1080/15257770701508521
• 作为产物：
  描述：

  阿昔洛韦 在 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 Succinic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethyl ester 2,5-dioxo-pyrrolidin-1-yl ester
  参考文献：
  名称：

  Rosemeyer, Helmut; Ahlers, Michael; Schmidt, Brigitta, Angewandte Chemie, 1985, vol. 97, # 6, p. 500 - 502

  摘要：

  DOI：