2-(3,4-Dichloro-phenylamino)-propionic acid hydrazide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(3,4-Dichloro-phenylamino)-propionic acid hydrazide
• 英文别名: 2-(3,4-dichloroanilino)propanehydrazide
• 化学式: C₉H₁₁Cl₂N₃O
• 分子量: 248.112
• InChiKey: JHOFHSOJIWLDEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3,4-Dichloro-phenylamino)-propionic acid hydrazide 、 香草醛 在 盐酸 作用下， 以 水 为溶剂， 反应 6.0h， 以83%的产率得到N'-(4-hydroxy-3-methoxybenzylidene)2-(3,4-dichlorophenylamino)propanehydrazide
  参考文献：
  名称：

  Synthesis of Potential Biologically Active Compounds Based on Aryloxy- and Arylaminopropanehydrazides

  摘要：

  New derivatives of a number of aryloxy and arylaminopropanehydrazides were synthesized. Their heterocyclization under the action of carbon disulfide and potassium hydroxide and subsequent alkylation of the resulting 2-thioxo-1,3,4-oxadiazole ring, the corresponding S-substituted products were obtained. The reaction of the starting hydrazides with arylaldehydes and pentane-2,4-dione afforded theirN '-arylidene and N '-(4-oxopentan-2-ylidene) derivatives. In preliminary laboratory tests, the synthesized compounds showed a pronounced stimulating effect on plant growth. Their activity was 44-95% compared with heteroauxin.

  DOI：

  10.1134/s1070363220070014