cis-endo-2,3-(bishydroxymethyl)-7-oxabicyclo<2.2.1>heptane | 68940-53-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: cis-endo-2,3-(bishydroxymethyl)-7-oxabicyclo<2.2.1>heptane
• 英文别名: [(1S,2R,3S,4R)-3-(hydroxymethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]methanol
• CAS: 68940-53-4
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: PTJQDBOAZMCIMB-KVFPUHGPSA-N

物化性质

• 熔点：
  63 °C
• 沸点：
  300.5±7.0 °C(Predicted)
• 密度：
  1.185±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cis-endo-2,3-(bishydroxymethyl)-7-oxabicyclo<2.2.1>heptane 以 various solvent(s) 为溶剂， 以72%的产率得到(+)-7-oxabicyclo<2.2.1>heptane-endo-2,endo-3-dimethanol monoacetate
  参考文献：
  名称：

  Andreu, Cecilia; Marco, J. Alberto; Asensio, Gregorio, Journal of the Chemical Society. Perkin transactions I, 1990, # 11, p. 3209 - 3210

  摘要：

  DOI：
• 作为产物：
  描述：

  cis-endo-2,3-(biscarbomethoxy)-7-oxabicyclo<2.2.1>heptane 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以66%的产率得到cis-endo-2,3-(bishydroxymethyl)-7-oxabicyclo<2.2.1>heptane
  参考文献：
  名称：

  Jones, J. Bryan; Francis, Christopher J., Canadian Journal of Chemistry, 1984, vol. 62, p. 2578 - 2582

  摘要：

  DOI：

文献信息

• Hydroxamic acids of 7-oxabicyclo[2.2.1]heptane substituted ethers useful
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04654366A1

  公开（公告）日：1987-03-31

  7-Oxabicycloheptane substituted ether or thio ether prostaglandin analogs are provided having the structural formula ##STR1## wherein A is O or ##STR2## and X is O or ##STR3## and including all stereoisomers thereof. The compounds are inhibitors of .DELTA..sup.5 -lipoxygenase and inhibitors of prostaglandin and leukotriene biosynthesis and as such are useful, for example, as antiallergy and antiinflammatory agents and also as antipsoriatic agents.

  提供了具有以下结构式的7-Oxabicycloheptane取代醚或硫醚前列腺素类似物：其中A为O或，X为O或，并包括所有立体异构体。这些化合物是.DELTA..sup.5-脂氧合酶的抑制剂，也是前列腺素和白三烯生物合成的抑制剂，因此可用作抗过敏和抗炎药物，也可用作抗银屑病药物。
• 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04536513A1

  公开（公告）日：1985-08-20

  7-Oxabicycloheptane substituted interphenylene prostaglandin ethers are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

  提供了具有结构式 ##STR1## 的7-氧代双环庚烷取代间苯二酚前列腺素醚，包括所有立体异构体。这些化合物是心血管药物，例如，在溶栓疾病的治疗中有用。
• 7-oxabicycloheptane-substituted oxa prostaglandin analogs and their use
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04588743A1

  公开（公告）日：1986-05-13

  7-Oxabicycloheptane substituted oxa prostaglandin analogs are provided having the structural formula ##STR1## wherein R is OH, ##STR2## (wherein R.sup.3 is lower alkyl, aryl, arylalkyl or lower alkylamino), ##STR3## (wherein R.sup.4 and R.sup.5 are the same or different and can be H, alkyl, aryl or arylalkyl, and R.sup.6 is alkyl or O-alkyl); R.sup.1 is lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl; R.sup.2 is hydrogen or lower alkyl; A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --; n is 1 to 4, and m is 1 to 8, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  提供了具有结构式的7-Oxabicycloheptane取代氧代前列腺素类似物##STR1##其中R为OH,##STR2##(其中R.sup.3为较低烷基、芳基、芳基烷基或较低烷氨基),##STR3##(其中R.sup.4和R.sup.5相同或不同，可以是H、烷基、芳基或芳基烷基，R.sup.6为烷基或O-烷基); R.sup.1为较低烷基、芳基、芳基烷基、环烷基或环烷基烷基; R.sup.2为氢或较低烷基; A为--CH.dbd.CH--或--(CH.sub.2).sub.2--; n为1至4，m为1至8，包括所有立体异构体。这些化合物是心血管药物，例如，在治疗血栓性疾病中有用。
• 7-oxabicycloheptane substituted prostaglandin interphenylene analogs
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0156245A1

  公开（公告）日：1985-10-02

  7-Oxabicycloheptane substituted interphenylene prostaglandin ethers are provided having the structural formula and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

  7-氧杂双环庚烷取代的间苯二酚前列腺素醚的结构式为 并包括其所有立体异构体。 这些化合物是心血管药物，可用于治疗血栓溶解疾病等。
• 7-Oxabicycloheptane substituted ethers
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0163562A1

  公开（公告）日：1985-12-04

  7-Oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula wherein A is O or and X is 0 or and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

  提供的 7-氧杂双环庚烷取代醚前列腺素类似物具有结构式，其中 A 为 O 或，X 为 0 或，包括其所有立体异构体。 这些化合物是心血管药物，可用于治疗血栓溶解疾病等。