申请人:President and Fellows of Harvard College
公开号:US20150328214A1
公开(公告)日:2015-11-19
The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting complex (APC) by a synergistic mechanism.
本公开提供了用于治疗细胞周期紊乱的组合物和方法。本公开的组合物包括proTAME和aPCin,它们的组合通过协同作用机制抑制负责有丝分裂后期促进复合物(APC)的活性或功能。其中,proTAME是TAME的前药类似物。