N,N'-Ethylen-bis-mercaptoacetamid | 692-93-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-Ethylen-bis-mercaptoacetamid
• 英文别名: Ethylene bis mercaptoacetamide；2-sulfanyl-N-[2-[(2-sulfanylacetyl)amino]ethyl]acetamide
• CAS: 692-93-3
• 化学式: C₆H₁₂N₂O₂S₂
• 分子量: 208.305
• InChiKey: SQPIKOWZWIINCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  60.2
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-Ethylen-bis-mercaptoacetamid 生成 perhydro 1,2-dithia-5,8-diazecine-4,9-dione
  参考文献：
  名称：

  Large-ring cyclic disulfide diamides

  摘要：

  DOI：

  10.1021/jo00945a021
• 作为产物：
  描述：

  巯基乙酸甲酯 、 乙二胺 生成 N,N'-Ethylen-bis-mercaptoacetamid
  参考文献：
  名称：

  潜在的抗辐射药物。I.巯基酸的酰胺，羟基酸和肼基衍生物。氨基硫辛酸。

  摘要：

  DOI：

  10.1021/jm00325a007

文献信息

• H3LMN COMPOUND USED AS RADIOACTIVE AGENT FOR TREATMENT OF LIVER CANCER AND MANUFACTURING METHOD THEREOF
  申请人：Liu Show-Wen

  公开号：US20110065904A1

  公开（公告）日：2011-03-17

  H 3 LMN series compounds used as radioactive agents for treatment of liver cancer and a manufacturing method thereof are revealed. 2-thioethylamine hydrochloride is reacted with triphenylmethanol for protection of thiol to obtain 2-[(triphenylmethyl)thio]ethylamine. Then obtain N-[2-((triphenylmethyl)thio)ethyl]chloroacetamide by a transamidation reaction between 2-[(triphenylmethyl)thio]ethylamine and chloroactyl chloride. Next produce a amine-amide-thiol ligand-N-[2-((triphenylmethyl)thio)ethyl][2-((triphenylmethyl)thio)ethylamino]acetamide by a substitution reaction of N-[2-((triphenylmethyl)thio)ethyl]chloroacetamide and 2-[(triphenylmethyl)thio]ethylamine. After respective reaction with 1-bromotetradecane, 1-bromohexadecane and ethyl 16-bromohexadecanoate, H 3 LMN series compounds are obtained. These amine-amide-dithiols quadridentate ligands can react with MO 3+ (M=Tc or Re) to produce electrically neutral complexes. The complexes have high lipophilicity, allowing them soluble in lipiodol to be applied to radiation therapy for liver cancer.

  LMN系列化合物被用作治疗肝癌的放射性药剂，以及其制造方法被揭示。2-硫乙胺盐酸盐与三苯甲醇反应以保护硫醇，得到2-[(三苯甲基)硫基]乙胺。然后通过2-[(三苯甲基)硫基]乙胺与氯乙酰氯之间的转酰胺反应获得N-[2-((三苯甲基)硫基)乙基]氯乙酰胺。接下来通过N-[2-((三苯甲基)硫基)乙基]氯乙酰胺和2-[(三苯甲基)硫基]乙胺的取代反应产生一种胺-酰胺-硫醇配体-N-[2-((三苯甲基)硫基)乙基][2-((三苯甲基)硫基)乙胺基]乙酰胺。在分别与1-溴四十二烷、1-溴十六烷和乙基-16-溴十六烷酸酯反应后，得到H3LMN系列化合物。这些胺-酰胺-二硫醇四齿配体可以与MO3+(M=Tc或Re)反应，产生电中性络合物。这些络合物具有高脂溶性，使它们可溶于碘油，用于肝癌的放射治疗。
• BIFUNCTIONAL COMPOUND WITH MONOSACCHARIDE AND N2S2 LIGAND, AND PREPARATION AND USE THEREOF
  申请人：LIU SHOW-WEN

  公开号：US20120009669A1

  公开（公告）日：2012-01-12

  A bifunctional compound with a monosaccharide and a N 2 S 2 ligand, and more particularly, a bifunctional compound with a N 2 S 2 ligand and aminohexylacetyl galactosamine (ah-GalNAc 4 ) is provided. A method for preparing the bifunctional compound with a monosaccharide and a N 2 S 2 ligand is also provided, including activating a carboxyl group in an organic ligand, reacting the activated carboxyl group with a galactopyranoside through amidation, and then hydrolyzing. The bifunctional compound of the present invention is widely useful in nuclear medicine for preparation of liver imaging agents for assisting in correct diagnosis of diseases.

  提供了一种具有单糖和N2S2配体的双功能化合物，更具体地说，提供了一种具有N2S2配体和氨基己酰半乳糖胺（ah-GalNAc4）的双功能化合物。还提供了一种制备具有单糖和N2S2配体的双功能化合物的方法，包括激活有机配体中的羧基，通过酰胺化将激活的羧基与半乳糖苷反应，然后水解。本发明的双功能化合物在核医学中广泛用于制备肝脏成像剂，以帮助正确诊断疾病。
• Bifunctional compound containing amino group and diaminedithiol ligand and manufacturing method thereof
  申请人：Liu Show-Wen

  公开号：US20110040123A1

  公开（公告）日：2011-02-17

  A bifunctional compound containing an amino group and diaminedithiol ligand and a manufacturing method thereof are revealed, the bifunctional compound includes at least one amino group and a diaminedithiol (N 2 S 2 ) ligand. The amino groups is for reacting with compounds containing carboxylic acids or halogens while the N 2 S 2 ligand binds with technetium or rhenium so as to form an anion complex. The thiol group in the N 2 S 2 ligand is protected by a protecting group for prevention of oxidation and easy storage. This protecting group is released easily during complex reactions. Due to the bifunctional property, the compound is applied to preparation of radiopharmaceuticals such as imaging agents and targeted agents.

  揭示了一种含有氨基和二胺二硫配体的双功能化合物及其制造方法，该双功能化合物包括至少一个氨基和一个二胺二硫（N2S2）配体。氨基用于与含有羧酸或卤素的化合物发生反应，而N2S2配体与锝或铼结合以形成阴离子络合物。N2S2配体中的硫醇基团通过保护基团进行保护，以防止氧化并便于储存。在复杂反应过程中，这种保护基团容易释放。由于具有双功能性质，该化合物被应用于制备放射性药物，如成像剂和靶向剂。
• [EN] BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME<br/>[FR] LIGANDS BROMODOMAINES BIVALENTS ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：COFERON INC

  公开号：WO2015081284A1

  公开（公告）日：2015-06-04

  Described herein are compounds capable of modulating one or more biomolecules substantially simultaneously, e.g., modulating two or more binding domains (e.g., bromodomains) on a protein or on different proteins. For example, in one aspect, a bivalent compound or a pharmaceutically acceptable salt, stereoisomer, metabolite, or hydrate thereof is provided. In another aspect, a method of treating a disease associated with a protein having tandem bromodomains in a patient in need thereof is provided. The method comprises administering to the patient the bivalent compound as described.

  本文描述了一种能够同时调节一个或多个生物分子的化合物，例如，在蛋白质上或在不同蛋白质上调节两个或更多结合结构域（例如溴结构域）。例如，在一个方面，提供了一种二价化合物或药用盐、立体异构体、代谢物或其水合物。在另一个方面，提供了一种治疗与患有串联溴结构域蛋白相关的疾病的方法，该方法包括向患者注射所述的二价化合物。
• Tetradentate N₂S₂ Vanadyl(IV) Coordination Complexes: Synthesis, Characterization, and Reactivity Studies
  作者：Roxanne M. Jenkins、Tiffany A. Pinder、Michelle L. Hatley、Joseph H. Reibenspies、Marcetta Y. Darensbourg

  DOI：10.1021/ic1022533

  日期：2011.3.7

  and FeII) while maintaining reactivity at the S-thiolate sites of the respective N2S2M complexes. The vanadyl ion, of interest for its pharmacological possibilities and its spin-label reporter properties for bioinorganic studies, also shows an affinity for such mixed nitrogen/sulfur-donor environments. Thus, (V≡O)2+ analogues of a well-characterized series of N2S2Ni complexes have been prepared as mimics

  多功能Ñ 2小号2四个齿配体（BME-DACO）2-，（BME-DACH）2-，和（EMA）4-已知容纳许多二价过渡金属离子（M =镍II，钯II，铂II，Pb II，Zn II，Cd II，Cu II和Fe II），同时在各个N 2 S 2的S-硫醇盐位点保持反应M配合物。钒氧离子因其药理学可能性及其在生物无机研究中的自旋标记报告基因特性而受到关注，它也显示出对这种混合氮/硫供体环境的亲和力。因此，已准备好一系列特征明确的N 2 S 2 Ni配合物的（V = O）2+类似物，作为由三肽基序的体内结合位点形成的可能的N 2 S 2（V = O）的模拟物， Cys-X-Cys。用烷基化剂探索了S-硫醇盐在这些系统中的亲核性。给出了IR [ν（VO）]，电子光谱和电子顺磁共振测量结果。（bme-daco）（V≡O），（bme-dach）（V≡O）和[Et 4N] 2 [（ema）（V ＝ O）

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