N-(4-aminopyridin-3-yl)-4-(tert-butyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-aminopyridin-3-yl)-4-(tert-butyl)benzamide
• 英文别名: N3-(4-tert-butylbenzoyl)-3,4-pyridinediamine；N-(4-aminopyridin-3-yl)-4-tert-butylbenzamide
• 化学式: C₁₆H₁₉N₃O
• 分子量: 269.346
• InChiKey: JJBCGFGALWNFAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(4-aminopyridin-3-yl)-4-(tert-butyl)benzamide 在 溶剂黄146 作用下， 反应 14.0h， 以27%的产率得到2-(4-(tert-butyl)phenyl)-1H-imidazo[4,5-c]pyridine
  参考文献：
  名称：

  WO2020033359A5

  摘要：

  公开号：

  WO2020033359A5
• 作为产物：
  描述：

  3,4-二氨基吡啶 、 对叔丁基苯甲酰氯 在 三乙胺 作用下， 反应 12.0h， 以34%的产率得到N-(4-aminopyridin-3-yl)-4-(tert-butyl)benzamide
  参考文献：
  名称：

  WO2020033359A5

  摘要：

  公开号：

  WO2020033359A5

文献信息

• Antithrombotic agents
  申请人：Eli Lilly and Company

  公开号：US06313151B1

  公开（公告）日：2001-11-06

  This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

  这项申请涉及到一种化合物（I）的公式，该化合物的药用盐或其前药，如本文所定义，以及其药物组合物，以及其作为Xa因子抑制剂的用途，以及其制备方法和中间体。
• 2-arylbenzimidazoles as PPARGC1A activators for treating neurodegenerative diseases
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10851066B2

  公开（公告）日：2020-12-01

  The compound 2-(3-tert-Butylphenyl)-4,6-difluoro-1H-benzo[d]imidazole and its use are disclosed: The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.

  公开了化合物 2-(3-叔丁基苯基)-4,6-二氟-1H-苯并[d]咪唑及其用途： 该化合物可激活 Ppargc1a，因此可用于治疗神经炎症和各种神经退行性疾病。
• 2-arylbenzimidazoles as Ppargc1a activators for treating neurodegenerative diseases
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US11111217B2

  公开（公告）日：2021-09-07

  The compound 2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-5-ol: and its use are disclosed. The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.

  化合物 2-(4-叔丁基苯基)-1H-苯并[d]咪唑-5-醇： 及其用途。该化合物能激活 Ppargc1a，因此可用于治疗神经炎症和各种神经退行性疾病。
• 2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20200299244A1

  公开（公告）日：2020-09-24

  The compound 2-(3-tert-Butylphenyl)-4,6-difluoro-1H-benzo[d]imidazole and its use are disclosed: The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.
• 2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20210300877A1

  公开（公告）日：2021-09-30

  A genus of compounds encompassed by formula (III) and their use is disclosed: The compounds activate Ppargc1a and, as a consequence, are useful for treating a variety of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, motor neuron diseases, and a demyelinating disease.