2-(4-formylphenyl)-4,5-dihydrooxazole | 882045-60-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-formylphenyl)-4,5-dihydrooxazole
• 英文别名: 4-(4,5-dihydro-1,3-oxazol-2-yl)benzaldehyde；4-(4,5-Dihydro-1,3-oxazol-2-yl)benzaldehyde
• CAS: 882045-60-5
• 化学式: C₁₀H₉NO₂
• 分子量: 175.187
• InChiKey: CCVOSXARWNHXHC-UHFFFAOYSA-N

物化性质

• 沸点：
  328.4±25.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-formylphenyl)-4,5-dihydrooxazole 、 甲基溴化镁 在 水 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 反应 4.25h， 生成 1-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenyl]-1-ethanol
  参考文献：
  名称：

  DIAGNOSTIC AND REMEDY FOR DISEASE CAUSED BY AMYLOID AGGREGATION AND/OR DEPOSITION

  摘要：

  公开号：

  EP1956013B1
• 作为产物：
  描述：

  4-(4,5-dihydrooxazol-2-yl) benzonitrile 在 二异丁基氢化铝 、 水 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 反应 22.17h， 生成 2-(4-formylphenyl)-4,5-dihydrooxazole
  参考文献：
  名称：

  DIAGNOSTIC AND REMEDY FOR DISEASE CAUSED BY AMYLOID AGGREGATION AND/OR DEPOSITION

  摘要：

  公开号：

  EP1956013B1

文献信息

• A Convenient Synthesis of Oxazolines and Imidazolines from Aromatic Aldehydes with Pyridinium Hydrobromide Perbromide in Water
  作者：Shinsei Sayama

  DOI：10.1055/s-2006-941597

  日期：2006.6

  Various 2-oxazolines were prepared from aromatic aldehydes and 2-aminoethanol with pyridinium hydrobromide per­bromide in water at room temperature. 2-Imidazolines were also obtained in good yields from aromatic aldehydes and ethylenediamine under the same reaction conditions.

  以吡啶溴氢溴化物为催化剂，室温下在水中用芳香醛和2-氨基乙醇制备了多种2-噁唑啉。在相同反应条件下，芳香醛和乙二胺也能获得较高产率的2-咪唑啉。
• A General and Efficient Palladium-Catalyzed Carbonylative Synthesis of 2-Aryloxazolines and 2-Aryloxazines from Aryl Bromides
  作者：Xiao-Feng Wu、Helfried Neumann、Stephan Neumann、Matthias Beller

  DOI：10.1002/chem.201202652

  日期：2012.10.22

  Oxazoline is OK! A general and efficient method for the synthesis of oxazolines has been developed (see scheme). This allowed the preparation of 27 five‐membered‐ring heterocycles and 11 six‐membered‐ring heterocycles in moderate to good yields.

  恶唑啉还可以！已经开发了一种合成恶唑啉的通用有效方法（参见方案）。这允许以中等至良好的产率制备27个五元环杂环和11个六元环杂环。
• Ruthenium(II) 8-quinolinolates: Synthesis, characterization, crystal structure and catalysis in the synthesis of 2-oxazolines
  作者：P. Anitha、R. Manikandan、G. Prakash、B. Pachiyappan、P. Viswanathamurthi、J.G. Malecki

  DOI：10.1016/j.jorganchem.2015.06.005

  日期：2015.8

  New octahedral ruthenium(II) complexes (1-4) have been synthesized from the reaction of ruthenium( II) precursors [RuHCl(CO)(EPh3)(3)] (E - P or As) with the bidentate Schiff base ligands, 2-((2,6-dimethylphenylimino) methyl) quinolin-8-ol (L-1) and 2-((2,6-diisopropylphenylimino) methyl) quinolin-8-ol (L-2) in ethanol. These complexes have been characterized by elemental analyses, IR, UV-Vis, H-1, C-13 and P-31 NMR and ESI-Mass spectroscopy. The molecular structure of the complex [RuCl(CO)(PPh3)(2)(L-2)] (2) was determined by single-crystal X-ray diffraction, which reveals a distorted octahedral geometry around ruthenium(II) ion. The catalytic activity of the new complexes was evaluated for the condensation of nitriles with ethanolamine under solvent free conditions. The processes were operative with aromatic and heteroaromatic nitriles and tolerated several substitutional groups. The studies on the effect of substitution over ligands, coligands, reaction time, temperature and catalyst loading were carried out in order to find the best catalyst in this series of complexes and favorable reaction conditions. A probable mechanism for the catalytic condensation of nitrile has also been proposed. The catalyst was recovered and recycled up to five times without significant loss of its activity. (C) 2015 Elsevier B.V. All rights reserved.
• POLYMER-FILLER COUPLING ADDITIVES
  申请人：Bridgestone Corporation

  公开号：EP1802593B1

  公开（公告）日：2013-04-24
• US8022075B2
  申请人：——

  公开号：US8022075B2

  公开（公告）日：2011-09-20