N-acetyl-S-palmitoyl cysteine | 62146-99-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-S-palmitoyl cysteine
• 英文别名: S-Palmitolyl-N-acetyl-L-cystein；(2R)-2-acetamido-3-hexadecanoylsulfanylpropanoic acid
• CAS: 62146-99-0
• 化学式: C₂₁H₃₉NO₄S
• 分子量: 401.611
• InChiKey: MBMXWSZNOFJZBO-IBGZPJMESA-N

物化性质

• 熔点：
  61-63 °C(Solv: acetone (67-64-1))
• 沸点：
  567.6±45.0 °C(Predicted)
• 密度：
  1.037±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  27
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-乙酰-L-半胱氨酸 、 棕榈酰氯 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-acetyl-S-palmitoyl cysteine
  参考文献：
  名称：

  Portelli; Renzi; Cervato, Farmaco, Edizione Scientifica, 1976, vol. 31, # 11, p. 767 - 775

  摘要：

  DOI：

文献信息

• A convenient solid phase synthesis of S-palmitoyl transmembrane peptides
  作者：Dirk T.S. Rijkers、John A.W. Kruijtzer、J. Antoinette Killian、Rob M.J. Liskamp

  DOI：10.1016/j.tetlet.2005.03.079

  日期：2005.5

  S-Palmitoylated peptides are important tools as models for integral membrane proteins to study peptide-lipid interactions. Herein, we report a convenient solid phase synthesis of S-palinitoyl transmembrane peptides. The highly acid labile S-(4-methoxytrityl) group is preferred over the S-(tert-butylsulfanyl) group for protection of the cysteine side chain since the latter gives rise to quantitative desulfurization during on-resin deprotection. The resulting free thiol function is modified with palmitic acid via a carbodinnide-inediated Coupling and the title compounds are obtained in good yields and purity. (c) 2005 Elsevier Ltd. All rights reserved.
• FOOD PRODUCTS, PREPARATION, AND THERAPEUTIC METHODS
  申请人：Schloss John V.

  公开号：US20120322868A1

  公开（公告）日：2012-12-20

  A method is provided for the supplementation of milk, dairy products, meat products, and other food substances generally considered to be a major part of the Western diet, with substances capable of balancing the ratio of methionine and cysteine. Drug therapy with various carbamoyl thioesters or glutamate receptor antagonists can also be used, alone or in combination with dietary supplements and vitamins, to prevent or treat the pathology resulting from a Western diet.
• Portelli; Renzi; Cervato, Farmaco, Edizione Scientifica, 1976, vol. 31, # 11, p. 767 - 775
  作者：Portelli、Renzi、Cervato、Frigeni

  DOI：——

  日期：——