N^α-chloroacetyl-D-tryptophan | 742100-62-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N^α-chloroacetyl-D-tryptophan
• 英文别名: N^α-Chloracetyl-D-tryptophan；N-(2chloroacetyl)-d-tryptophan；(2R)-2-[(2-chloroacetyl)amino]-3-(1H-indol-3-yl)propanoic acid
• CAS: 742100-62-5
• 化学式: C₁₃H₁₃ClN₂O₃
• 分子量: 280.711
• InChiKey: PGTJUXHMJYBSBW-LLVKDONJSA-N

物化性质

• 熔点：
  159 °C
• 沸点：
  610.2±55.0 °C(Predicted)
• 密度：
  1.428±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N^α-chloroacetyl-D-tryptophan 在 硫酸 、 水 作用下， 生成 D-色氨酸
  参考文献：
  名称：

  Gilbert et al., Journal of Biological Chemistry, 1949, vol. 180, p. 473,475

  摘要：

  DOI：
• 作为产物：
  描述：

  2-[(2-氯乙酰基)氨基]-3-(1H-吲哚-3-基)丙酸 生成 L-色氨酸 、 N^α-chloroacetyl-D-tryptophan
  参考文献：
  名称：

  Gilbert et al., Journal of Biological Chemistry, 1949, vol. 180, p. 473,475

  摘要：

  DOI：

文献信息

• Macrocyclic Peptide, Method for Producing Same, and Screening Method Using Macrocyclic Peptide Library
  申请人：THE UNIVERSITY OF TOKYO

  公开号：US20160209421A1

  公开（公告）日：2016-07-21

  An object of the present invention is to provide a peptide excellent in resistance against metabolism, having a stable structure in vivo, and capable of penetrating a cell membrane and reaching in cells. The present invention provides a macrocyclic peptide having a macrocyclic structure comprised of four or more amino acids. At least two amino acids not adjacent to each other have a hydrophobic side chain and the hydrophobic side chains interact with each other inside the ring of the macrocyclic peptide in a hydrophilic environment.

  本发明的目的是提供一种具有抗代谢能力、在体内具有稳定结构、能够穿透细胞膜并进入细胞的肽。本发明提供一种具有四个或更多氨基酸构成的大环肽，其具有大环结构。至少有两个不相邻的氨基酸具有疏水侧链，并且这些疏水侧链在大环肽的环内在亲水环境中相互作用。
• RAPID DISPLAY METHOD IN TRANSLATIONAL SYNTHESIS OF PEPTIDE
  申请人：PeptiDream Inc.

  公开号：EP2492344A9

  公开（公告）日：2013-02-20

  Provided are linkers suitable for preparing a conjugate of a nucleic acid and a peptide as a translation product thereof in a reconstituted cell-free translation system in genotype-phenotype mapping (display methods), said linkers comprising a single-stranded structure region having a side chain base pairing with the base at the 3'-end of an mRNA at one end and a peptidyl acceptor region containing an amino acid attached to an oligo RNA consisting of a nucleotide sequence of ACCA via an ester bond at the other end, characterized in that the ester bond is formed by using an artificial RNA catalyst. Also provided are display methods using [mRNA] - [linker] - [peptide] conjugates assembled via such linkers.

  所提供的连接体适用于在基因型-表型图谱（显示方法）中的重组无细胞翻译系统中制备核酸和肽的共轭物，作为其翻译产物、所述连接体包括单链结构区，其一端具有与 mRNA 3'- 端碱基配对的侧链碱基，另一端含有通过酯键连接到由 ACCA 核苷酸序列组成的寡核苷酸 RNA 上的氨基酸的肽基受体区，其特征在于酯键是通过使用人工 RNA 催化剂形成的。还提供了使用通过这种连接体组装的[mRNA]-[连接体]-[肽]共轭物的显示方法。
• TRANSLATION AND CONSTRUCTION OF NON-STANDARD PEPTIDE COMPOUND LIBRARY CONTAINING N-METHYL AMINO ACIDS AND OTHER NON-STANDARD AMINO ACIDS, AND METHOD FOR SEARCHING FOR ACTIVE SPECIES
  申请人：The University of Tokyo

  公开号：EP2615455A1

  公开（公告）日：2013-07-17

  A method for screening a non-standard peptide compound in the peptide library that binds to the target substance, comprising the steps: (i) preparing a non-standard peptide library wherein a special (non-standard) amino acid is randomly incorporated into the peptide sequence by a cell-free (in vitro) translation system comprising a tRNA acylated by a special (non-standard) amino acid; (ii) bringing the obtained peptide library in contact with a target substance; and (iii) selecting a non-standard peptide that binds to the target substance as an active peptide.

  一种在多肽文库中筛选与目标物质结合的非标准多肽化合物的方法，包括以下步骤：(i) 制备非标准肽库，其中通过无细胞（体外）翻译系统将特殊（非标准）氨基酸随机加入到肽序列中，该系统包括由特殊（非标准）氨基酸酰化的 tRNA；(ii) 将获得的肽库与目标物质接触；以及 (iii) 挑选出与目标物质结合的非标准肽作为活性肽。
• PEPTIDE FOR INHIBITING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR
  申请人：The University of Tokyo

  公开号：EP2894161A1

  公开（公告）日：2015-07-15

  An object of the present invention is to provide a VEGFR2 inhibitor peptide having high specificity and available at a low cost. The present invention provides a peptide having the following amino acid sequence: [wherein, Xaa2 represents Val or derivative thereof, Xaa6 represents Asp or derivative thereof, Xaa7 represents Pro or derivative thereof, Xaa8 represents Trp or derivative thereof, Xaa10 represents Asn or derivative thereof, Xaa11 represents Gly or derivative thereof, Xaa12 represents Leu or derivative thereof, Xaa1, Xaa3 to Xaa5, Xaa9, and Xaa13 to Xaa15 each independently represent an arbitrary amino acid or derivative thereof]; or [wherein, Xaa24 represents His or derivative thereof, Xaa25 represents Pro or derivative thereof, and Xaa16 to Xaa23 and Xaa26 to Xaa30 each represent an arbitrary amino acid].

  本发明的目的是提供一种具有高特异性且成本低廉的 VEGFR2 抑制剂多肽。本发明提供了一种具有以下氨基酸序列的多肽： [其中，Xaa2代表Val或其衍生物，Xaa6代表Asp或其衍生物，Xaa7代表Pro或其衍生物，Xaa8代表Trp或其衍生物，Xaa10代表Asn或其衍生物，Xaa11代表Gly或其衍生物，Xaa12代表Leu或其衍生物，Xaa1、Xaa3至Xaa5、Xaa9和Xaa13至Xaa15各自独立地代表任意氨基酸或其衍生物]；或 [其中，Xaa24 代表 His 或其衍生物，Xaa25 代表 Pro 或其衍生物，以及 Xaa16 至 Xaa23 和 Xaa26 至 Xaa30 各自代表任意氨基酸]。
• MACROCYCLIC PEPTIDE, METHOD FOR PRODUCING SAME, AND SCREENING METHOD USING MACROCYCLIC PEPTIDE LIBRARY
  申请人：The University of Tokyo

  公开号：EP3040417A1

  公开（公告）日：2016-07-06

  An object of the present invention is to provide a peptide excellent in resistance against metabolism, having a stable structure in vivo, and capable of penetrating a cell membrane and reaching in cells. The present invention provides a macrocyclic peptide having a macrocyclic structure comprised of four or more amino acids. At least two amino acids not adjacent to each other have a hydrophobic side chain and the hydrophobic side chains interact with each other inside the ring of the macrocyclic peptide in a hydrophilic environment.

  本发明的目的是提供一种抗代谢能力极强、在体内结构稳定、能够穿透细胞膜并到达细胞内的多肽。 本发明提供了一种大环肽，它具有由四个或四个以上氨基酸组成的大环结构。至少两个互不相邻的氨基酸具有疏水侧链，疏水侧链在大环肽的环内亲水环境中相互作用。