2,2,3,4,4,5-六氯联苯 | 35065-28-2

• 物质功能分类: 分析化学 - 食品安全 - 二噁英，多氯联苯，呋喃
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,2,3,4,4,5-六氯联苯
• 中文别名: 2,2',3,3'-四氯-4,4'-二氨基二苯甲烷；2,2',3,4,4',5'-六氯联苯
• 英文名称: 2,2',3,4,4',5'-Hexachlorobiphenyl
• 英文别名: PCB 138；1,2,3-trichloro-4-(2,4,5-trichlorophenyl)benzene
• CAS: 35065-28-2
• 化学式: C₁₂H₄Cl₆
• 分子量: 360.882
• InChiKey: RPUMZMSNLZHIGZ-UHFFFAOYSA-N

物化性质

• 熔点：
  80°C
• 沸点：
  446.99°C (rough estimate)
• 密度：
  1.5940 (rough estimate)
• 闪点：
  -12 °C
• 溶解度：
  可溶于氯仿（少许）、二氯甲烷（少许）
• 蒸汽压力：
  3.79e-06 mmHg
• 亨利常数：
  2.10e-05 atm-m3/mole
• 保留指数：
  2350;2311;2360.3;2343.7;2324;2358.6;2353.1;2343.1;2311.2;2319.9;2345.4;2354;2356;2355;2364;2343;2343;2343;2390

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

代谢

多氯联苯（PCBs）通过吸入、口服和皮肤接触途径被吸收。它们通过血液传输，通常与白蛋白结合。由于其亲脂性，它们倾向于在富含脂质的组织中积累，如肝脏、脂肪组织和皮肤。多氯联苯的代谢非常缓慢，并且根据氯化的程度和位置而有所不同。多氯联苯通过微粒体单加氧酶系统代谢，该系统由细胞色素P-450酶催化，转化为极性代谢物，这些代谢物可以与谷胱甘肽和葡萄糖醛酸结合。主要的代谢物是羟基化产物，通过胆汁和粪便排出。多氯联苯的缓慢代谢意味着它们倾向于在身体组织中积累。

PCBs are absorbed via inhalation, oral, and dermal routes of exposure. They are trasported in the blood, often bound to albumin. Due to their lipophilic nature they tend to accumulate in lipid-rich tissues, such as the liver, adipose, and skin. Metabolism of PCBs is very slow and varies based on the degree and position of chlorination. PCBs are metabolized by the microsomal monooxygenase system catalyzed by cytochrome P-450 enzymes to polar metabolites that can undergo conjugation with glutathione and glucuronic acid. The major metabolites are hydroxylated products which are excreted in the bile and faeces. The slow metabolism of PCBs means they tend to accumulate in body tissues. (L4, T6)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

PCB的作用机制因具体类型而异。类二噁烷PCB通过结合芳基烃受体，通过改变基因的转录来扰乱细胞功能，主要是通过诱导肝脏第一阶段和第二阶段酶的表达，特别是细胞色素P450家族。PCB的大多数毒性效应被认为是由Ah受体结合的结果。其他PCB被认为会干扰钙通道和/或改变大脑中的多巴胺水平。PCB还通过改变甲状腺激素的生成和结合到雌激素受体来引起内分泌紊乱，这可以刺激某些癌细胞的生长并产生其他雌激素效应，如生殖功能障碍。它们会通过结合到如uteroglobin等受体蛋白而生物累积。(A3, A4, A30, A66)

The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

1, 对人类致癌。

1, carcinogenic to humans. (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

PCBs最常见的健康影响是皮肤状况，如氯痤疮和皮疹。长期暴露于PCBs还可能导致肝脏、胃和肾脏损害、黄疸、水肿、贫血、免疫系统变化、行为改变以及生殖能力受损。

The most common health effects of PCBs are skin conditions such as chloracne and rashes. Chronic PCB exposure has also been shown to cause liver, stomach and kidney, damage, jaundice, edema, anemia, changes in the immune system, behavioral alterations, and impaired reproduction. (L4)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L4级）；吸入（L4级）；皮肤给药（L4级）

Oral (L4) ; inhalation (L4) ; dermal (L4)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

慢性 PCB 暴露会导致如下症状：腹痛、恶心、呕吐、腹泻、头痛、眩晕、抑郁、神经紧张、皮肤和眼睛损伤、疲劳、月经周期不规律以及免疫力下降。

Chronic PCB exposure results in symptoms such as abdominal pain, nausea, vomiting, diarrhea, headache, dizziness, depression, nervousness, dermal and ocular lesions, fatigue, irregular menstrual cycles and a lowered immune response. (A3)

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• 危险等级：
  9
• 危险品标志：
  Xn,F,N
• 安全说明：
  S16,S29,S33,S35,S60,S61,S62,S9
• 危险类别码：
  R11
• WGK Germany：
  2,3
• 危险品运输编号：
  UN 2315
• 包装等级：
  II
• 危险类别：
  9
• 储存条件：
  | 2-8°C |

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : PCB No 138 solution
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Flammable liquids (Category 2)
Skin irritation (Category 2)
Specific target organ toxicity - single exposure (Category 3)
Aspiration hazard (Category 1)
Acute aquatic toxicity (Category 1)
Chronic aquatic toxicity (Category 1)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Highly flammable. Harmful: may cause lung damage if swallowed. Irritating to skin. Vapours may cause
drowsiness and dizziness. Very toxic to aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Danger
Hazard statement(s)
H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P273 Avoid release to the environment.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/
physician.
P331 Do NOT induce vomiting.
P501 Dispose of contents/ container to an approved waste disposal plant.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R11 Highly flammable.
R38 Irritating to skin.
R65 Harmful: may cause lung damage if swallowed.
R67 Vapours may cause drowsiness and dizziness.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s)
S9 Keep container in a well-ventilated place.
S16 Keep away from sources of ignition - No smoking.
S29 Do not empty into drains.
S33 Take precautionary measures against static discharges.
S60 This material and its container must be disposed of as hazardous waste.
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
S62 If swallowed, do not induce vomiting: seek medical advice immediately
and show this container or label.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Mixtures
: 2,2′,3,4,4′,5′-PCB
Synonyms
2,2′,3,4,4′,5′-Hexachlorobiphenyl
Component Classification Concentration
2,2,4-Trimethylpentane
CAS-No. 540-84-1 Flam. Liq. 2; Skin Irrit. 2; 50 - 100 %
EC-No. 208-759-1 STOT SE 3; Asp. Tox. 1;
Index-No. 601-009-00-8 Aquatic Acute 1; Aquatic
Chronic 1; H225, H304, H315,
H336, H410
F, Xn, N, R11 - R38 - R65 -
R67 - R50/53
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or
spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of
water.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature: 2 - 8 °C
Specific end use(s)
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
of protective equipment must be selected according to the concentration and amount of the
dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point -12 °C - closed cup
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
Heat, flames and sparks. Extremes of temperature and direct sunlight.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation. Vapours may
cause drowsiness and dizziness.
Ingestion May be harmful if swallowed. Aspiration hazard if swallowed - can enter
lungs and cause damage.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
Very toxic to aquatic life with long lasting effects.

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
company. Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: 1262 IMDG: 1262 IATA: 1262
UN proper shipping name
ADR/RID: OCTANES
IMDG: OCTANES
IATA: Octanes
Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: yes IMDG Marine Pollutant: yes IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available

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Section 16. OTHER INFORMATION
Text of H-code(s) and R-phrase(s) mentioned in Section 3
Aquatic Acute Acute aquatic toxicity
Aquatic Chronic Chronic aquatic toxicity
Asp. Tox. Aspiration hazard
Flam. Liq. Flammable liquids
H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H410 Very toxic to aquatic life with long lasting effects.
Skin Irrit. Skin irritation
STOT SE Specific target organ toxicity - single exposure
F Highly flammable
N Dangerous for the environment
Xn Harmful
R11 Highly flammable.
R38 Irritating to skin.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic
environment.
R65 Harmful: may cause lung damage if swallowed.
R67 Vapours may cause drowsiness and dizziness.
Further information
Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

反应信息

• 作为反应物：
  描述：

  2,2,3,4,4,5-六氯联苯 在 氧气 作用下， 生成 1,3,4,6,7-五氯二苯并呋喃
  参考文献：
  名称：

  Synthesis of the 38 tetrachlorodibenzofuran isomers and identification by capillary column gas chromatography mass spectrometry

  摘要：

  DOI：

  10.1021/ac00252a028
• 作为产物：
  描述：

  2,4,5-三氯苯胺 、 三氯苯 在 亚硝酸异戊酯 作用下， 生成 2,2,3,4,4,5-六氯联苯
  参考文献：
  名称：

  Physical, spectral and chromatographic properties of all 209 individual PCB congeners

  摘要：

  Physical, spectral and chromatographic data for all 209 individual PCB congeners is presented. The individual congeners were synthesized and then isolated and purified. Recent emphasis on the source of the toxicity of commercial PCB formulations has increased the need for a complete set of the PCB congeners. Through the use of two capillary GC columns: 40% octadecyl/ 15% phenyl methyl siloxane and 50% phenyl methyl siloxane, it was possible to separate 201 PCB congeners with only four unresolved pairs. The data compiled in this study for all 209 congeners will aid in the identification of selected individual components of these environmental pollutants. The use of this data also presents the opportunity for the improved quantification of the commercial PCB formulations.

  DOI：

  10.1016/0045-6535(95)00140-4

文献信息

• Instruments for detecting low-molecular weight substance
  申请人：Mizukami Haruki

  公开号：US20050148097A1

  公开（公告）日：2005-07-07

  To provide the following instruments 1 and 2 as a low-molecular-weight substance detection instrument employing immunochromatography capable of detecting conveniently and sensitively detecting a low-molecular weight substance such as an environmental pollutant (e.g., a dioxin), as a target substance contained in a test sample: 1. an instrument, which comprises 1) a test sample application section with which a test sample is brought into contact; 2) a label product reaction section containing a label product containing, as a portion thereof, an antibody capable of binding to a target substance contained in the test sample, the label product being not bound to the reaction section; 3) an unbound label product capturing section containing an element capable of capturing the label product which is not bound to the target substance, the element being bound to the capturing section; and 4) a detection section containing a detection element which, when coming into contact with the target substance bound to the label product, causes a visually observable change, and 2. an instrument wherein a test sample is reacted with a labeled antibody containing, as a portion thereof, an antibody capable of binding to a target substance contained in the test sample, and the resultant reaction product is employed for detecting the target substance contained in the test sample.

  提供以下仪器1和2作为低分子量物质检测仪器，采用免疫层析技术，能够方便敏感地检测低分子量物质，例如环境污染物（例如二恶英），作为测试样品中包含的目标物质：1. 仪器，包括1）测试样品应用部分，用于将测试样品接触；2）标签产物反应部分，包含一种标签产物，其中包含一种能够结合到测试样品中的目标物质的抗体，标签产物未结合到反应部分；3）未结合标签产物捕获部分，包含一种能够捕获未结合到目标物质的标签产物的元素，该元素与捕获部分结合；以及4）检测部分，包含一种检测元素，当与结合到标签产物的目标物质接触时，会引起可视的变化；2. 仪器，其中测试样品与标记抗体反应，其中一部分包含能够结合到测试样品中的目标物质的抗体，产生的反应产物用于检测测试样品中包含的目标物质。
• INSTRUMENTS FOR DETECTING LOW-MOLECULAR WEIGHT SUBSTANCE
  申请人：Enbiotec Laboratories Co., Ltd.

  公开号：EP1489420A1

  公开（公告）日：2004-12-22

  To provide the following instruments 1 and 2 as a low-molecular-weight substance detection instrument employing immunochromatography capable of detecting conveniently and sensitively detecting a low-molecular weight substance such as an environmental pollutant (e.g., a dioxin), as a target substance contained in a test sample: 1. an instrument, which comprises 1) a test sample application section with which a test sample is brought into contact; 2) a label product reaction section containing a label product containing, as a portion thereof, an antibody capable of binding to a target substance contained in the test sample, the label product being not bound to the reaction section; 3) an unbound label product capturing section containing an element capable of capturing the label product which is not bound to the target substance, the element being bound to the capturing section; and 4) a detection section containing a detection element which, when coming into contact with the target substance bound to the label product, causes a visually observable change, and 2. an instrument wherein a test sample is reacted with a labeled antibody containing, as a portion thereof, an antibody capable of binding to a target substance contained in the test sample, and the resultant reaction product is employed for detecting the target substance contained in the test sample.

  提供以下仪器 1 和 2，作为一种采用免疫层析技术的低分子量物质检测仪器，能够方便、灵敏地检测作为检测样品中目标物质的低分子量物质，如环境污染物（如二恶英）： 1.仪器，包括：1）测试样品应用部分，测试样品与之接触；2）标签产品反应部分，包含标签产品，作为其一部分，该标签产品含有能够与测试样品中所含目标物质结合的抗体，标签产品未与反应部分结合；3) 非结合标签产品捕获部分，包含能够捕获未与目标物质结合的标签产品的元件，该元件与捕获部分结合；以及 4) 检测部分，包含检测元件，该元件与结合在标签产品上的目标物质接触时，会引起视觉上可观察到的变化，以及 2. 2. 一种仪器，其中测试样品与标记抗体反应，标记抗体的一部分能够与测试样品中的目标物质结合，反应产物用于检测测试样品中的目标物质。
• Rapid and sensitive method for measuring PCB contamination
  申请人：——

  公开号：US20030054424A1

  公开（公告）日：2003-03-20

  Immunoassay methods and standards are provided for determining the presence of polychlorinated biphenyl compounds, in a sample of interest: (a) extracting PCB compounds from the sample into a nonpolar solvent that will dissolve the PCB, to produce an analyte extract, (b) contacting the analyte extract with an mAB with specific reactivity towards PCB compounds under conditions suitable for the monoclonal antibody to bind to the PCBs present in the sample, (c) measuring mAB that is selectively bound to PCB compounds and congeners thereof, to provide a binding level, (d) relating the binding level of the mAB of step (c) with binding levels of the same mAB with a control composition, wherein the control composition comprises a plurality of PCB of compounds of known concentration, and then determining concentrations of PCB compounds in the sample.

  本研究提供了免疫测定方法和标准，用于确定相关样品中是否存在多氯联苯化合物： (a) 将样品中的多氯联苯化合物萃取到能溶解多氯联苯的非极性溶剂中，生成分析物萃取液、 (b) 在适合单克隆抗体与样品中的多氯联苯结合的条件下，将分析物提取物与对多氯联苯化合物具有特异反应性的 mAB 接触、 (c) 测量与多氯联苯化合物及其同系物选择性结合的 mAB，以提供结合水平、 (d) 将步骤(c)中 mAB 的结合水平与相同 mAB 与对照组合物的结合水平进行比较，其中对照组合物包括多种已知浓度的多氯联苯化合物，然后确定样品中多氯联苯化合物的浓度。
• Reactivity features of polychlorobiphenyl congeners in the nucleophilic substitution reactions
  作者：T. I. Gorbunova、M. G. Pervova、V. I. Saloutin、O. N. Chupakhin

  DOI：10.1134/s1070363212010227

  日期：2012.1

  Groups of congeners and individual congeners of polychlorobiphenyls contributing to the composition of the technical mixture "Sovol" (PCB 60, PCB 64, PCB 70, PCB 74, PCB 97, PCB 101, PCB 105, PCB 110, PCB 118, PCB 138, PCB 149, PCB 156, and PCB 163) were synthesized by the reaction of aryl-aryl coupling. The interaction of the congeners with sodium methoxide was performed and their complete conversion was proved. By means of gas chromatography-mass spectrometry the PCBs methoxy derivatives were identified. The data on the reactivity of the individual polychlorobiphenyl congeners were precised.
• DUEBELBEIS, D. O.;KAPILA, S.;CLEVENGER, T.;YANDERS, A. F.;MANAHAN, S. E., CHEMOSPHERE, 18,(1989) N-6, C. 101-108
  作者：DUEBELBEIS, D. O.、KAPILA, S.、CLEVENGER, T.、YANDERS, A. F.、MANAHAN, S. E.

  DOI：——

  日期：——

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