(3R,5R,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanenitrile | 224579-95-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3R,5R,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanenitrile
• CAS: 224579-95-7
• 化学式: C₂₃H₃₉NO₄Si
• 分子量: 421.652
• InChiKey: CVBSIYZXRVRQNQ-JXHRLWIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.29
• 重原子数：
  29.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  71.71
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (3R,5R,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanenitrile 在 2,6-二甲基吡啶 、 正丁基锂 、 N-甲基吲哚酮 、 四丙基高钌酸铵 、 二异丁基氢化铝 作用下， 以 正己烷 为溶剂， 生成 [(4S,6R,7S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-6,7-dimethyl-2-oxo-octyl]-phosphonic acid dimethyl ester
  参考文献：
  名称：

  2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector

  摘要：

  In the preceding letter, we described a synthesis of the conserved C.1-C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00207-5
• 作为产物：
  描述：

  tert-Butyl-[(2S,3R)-3-(4-methoxy-benzyloxy)-2,3-dimethyl-hex-5-enyloxy]-dimethyl-silane 在 potassium osmate(VI) 、 (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan) 、 lithium perchlorate 、 sodium hydride 、 1-对甲基苯磺酰咪唑 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 36.0h， 生成 (3R,5R,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-(4-methoxy-benzyloxy)-5,6-dimethyl-heptanenitrile
  参考文献：
  名称：

  2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector

  摘要：

  In the preceding letter, we described a synthesis of the conserved C.1-C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00207-5