四乙基醋酸铵 | 1185-59-7

• 物质功能分类: 化学试剂 - 有机试剂 - 胺盐（铵盐）
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 四乙基醋酸铵
• 中文别名: 四乙酯铵乙酸
• 英文名称: tetraethylammonium acetate
• 英文别名: tetraethylazanium;acetate
• CAS: 1185-59-7
• 化学式: C₂H₃O₂*C₈H₂₀N
• 分子量: 189.298
• InChiKey: GTCDARUMAMVCRO-UHFFFAOYSA-M

物化性质

• 熔点：
  42-46 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  0.64
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  F
• 安全说明：
  S16
• 危险类别码：
  R11
• WGK Germany：
  3
• 海关编码：
  2923900090
• 危险品运输编号：
  UN 1325 4.1/PG 2
• 储存条件：
  存储于室温环境。

SDS

Name:	Tetraethylammonium acetate tetrahydrate 99% Material Safety Data Sheet
Synonym:	Ethanaminium, N,N,N-triethyl-, acetate, tetrahydrate
CAS:	1185-59-7

Section 1 - Chemical Product MSDS Name:Tetraethylammonium acetate tetrahydrate 99% Material Safety Data Sheet
Synonym:Ethanaminium, N,N,N-triethyl-, acetate, tetrahydrate

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1185-59-7	Tetraethylammonium acetate tetrahydrat	99	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Hygroscopic (absorbs moisture from the air).The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Containers may explode in the heat of a fire. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 1185-59-7: CAS# 67533-12-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: colorless to white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 42.00 - 46.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: 60 deg C ( 140.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density:
Molecular Formula: C10H23NO2.4H2O
Molecular Weight: 261.35

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, dust generation, excess heat, temperatures above 65C, strong oxidants, exposure to moist air or water.
Incompatibilities with Other Materials:
Moisture, oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen, acetic acid.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1185-59-7 unlisted.
CAS# 67533-12-4 unlisted.
LD50/LC50:
Not available.
Not available.
Carcinogenicity:
Tetraethylammonium acetate anhydrous - Not listed by ACGIH, IARC, or NTP.
Tetraethylammonium acetate tetrahydrate - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 33 Take precautionary measures against static
discharges.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 1185-59-7: No information available.
CAS# 67533-12-4: No information available.
Canada
CAS# 1185-59-7 is listed on Canada's NDSL List.
CAS# 1185-59-7 is not listed on Canada's Ingredient Disclosure List.
CAS# 67533-12-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1185-59-7 is listed on the TSCA inventory.
CAS# 67533-12-4 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1-碘丁烷 、 四乙基醋酸铵 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 乙酸丁酯
  参考文献：
  名称：

  CATHODIC ESTERIFICATION OF CARBOXYLIC ACIDS

  摘要：

  发现了一种在温和条件下对羧酸进行酯化的阴极方法。酯化反应在室温下顺利进行，通过烷基化试剂与在阴极室中形成的季铵羧酸盐反应。

  DOI：

  10.1246/cl.1985.371
• 作为产物：
  描述：

  Et4N(UO2acet3) 以 neat (no solvent) 为溶剂， 生成 四乙基醋酸铵 、 三乙胺
  参考文献：
  名称：

  Santalova, N. A.; Seisenbaeva, G. A.; Dunaeva, K. M., Doklady Chemistry, 1988, vol. 300, p. 182 - 184

  摘要：

  DOI：
• 作为试剂：
  描述：

  甲基苯乙烯 在 甲基三氧化铼(VII) 四氧化锇 、 (DNQD)2PHAL 、 四乙基醋酸铵 作用下， 以 叔丁醇 为溶剂， 生成 (1R,2R)-1-phenylpropane-1,2-diol 、 (1S,2S)-1-phenyl-1,2-propanediol
  参考文献：
  名称：

  MTO和OsO4：有效的催化偶合剂，用于温和的基于H2O2的烯烃不对称二羟基化反应。

  摘要：

  已经开发了一种新颖而强大的体系，该体系用于通过H2O2与甲基三氧or（MTO）作为电子传递介体（ETM）来进行-催化的烯烃的不对称二羟基化。MTO催化手性配体的H2O2氧化为其一氧化氮，进而将OsVI再氧化为OsVIII。因此，（DHQD）2 PHAL既起手性感应剂的作用，又起叔胺的作用，产生生成recycling循环所需的N-氧化物。本发明的催化系统以良好的分离产率和高对映体过量（高达99％ee）提供邻邻二醇。

  DOI：

  10.1002/chem.200304828

文献信息

• [EN] HCV NS3 PROTEASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PROTÉASE NS3 DU VHC
  申请人：MERCK SHARP & DOHME

  公开号：WO2014025736A1

  公开（公告）日：2014-02-13

  The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.

  这项发明涉及含有螺环结构基团的丙型肝炎病毒（HCV）NS3蛋白酶抑制剂，以及这类化合物的用途和合成。
• Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation
  作者：Maria Chiara Pismataro、Nicole A. Horenstein、Clare Stokes、Marta Quadri、Marco De Amici、Roger L. Papke、Clelia Dallanoce

  DOI：10.1016/j.ejmech.2020.112669

  日期：2020.11

  The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity relationship investigation of the archetypal silent agonist NS6740 (1,4-diazabicyclo[3.2.2]nonan-4-yl(5-(3-(trifluoromethyl)-phenyl)-furan-2-yl)methanone)

  能够诱导受体脱敏并促进α7代谢功能的α7烟碱型乙酰胆碱受体（nAChR）沉默激动剂，正在成为新兴的新型治疗性抗炎药。在这里，我们报告原型沉默激动剂NS6740（1,4-二氮杂双环[3.2.2]壬南-4-基（5-（3-（三氟甲基）-苯基）-呋喃-2-基）的结构-活性关系研究）（甲酮）（1）阐明负责α7沉默激活的配体-受体相互作用。在这项研究中，NS6740片段11 - 16和类似物17 - 32设计，合成，并测定对表达的人α7烟碱受体爪蟾两电极电压钳制实验的卵母细胞。NS6740的所有结构部分对于产生其独特的活性谱至关重要。二氮杂双环核是必需的，但不足以诱导α7沉默激活。中央氢键受体核和芳族部分对于促进延长的α7受体结合和持续的脱敏至关重要。化合物13和17是有效的部分激动剂。化合物12，21，23 - 26，和30α7nAChR高度脱敏，因此可能对炎症反应的其他研究感兴趣。我们获得了有助于进一步沉默激动剂发展的关键结构信息。
• Total synthesis of (10ξ,15R,16S,19S,20S,34R)-Corossoline
  作者：Zhu-Jun Yao、Yu-Lin Wu

  DOI：10.1016/0040-4039(94)88189-8

  日期：1994.1

  (10ξ, 15R, 16S, 19S,20S,34R)-Corossoline, a structural representative of the cytotoxic monotetrahydrofuranyl annonaceous acetogenins, was synthesized from two chiral starting materials -- (S)-glutamic acid and (R)-ethyl lactate, and 10-undecenoic acid.

  （10ξ，15R，16S，19S，20S，34R）-去甲肾上腺素，是细胞毒性单四氢呋喃基壬酸产乙酸原素的结构代表，由两种手性起始原料合成-（S）-谷氨酸和（R）-乳酸乙酯，和10-十一碳烯酸。
• [EN] BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES<br/>[FR] HÉTÉROCYCLES D'AZOTE BICYCLIQUES ET PONTÉS
  申请人：CHEMOCENTRYX INC

  公开号：WO2005084667A1

  公开（公告）日：2005-09-15

  Compounds are provided that act as potent modulators of one or more of the CCR1, CCR2 and CCR3 receptors. The compounds are generally fused-, spiro- or bridged-nitrogen heterocycles having an aryl and heteroaryl component and are useful in pharmaceutical compositions, methods for the treatment of CCR1-, CCR2- and/or CCR3-mediated diseases, and as controls in assays for the identification of competitive receptor antagonists for the above chemokine receptors.

  提供了作为CCR1、CCR2和CCR3受体中一个或多个的有效调节剂的化合物。这些化合物通常是融合的、螺环的或桥联的氮杂环，具有芳基和杂芳基组分，并且在制药组合物、用于治疗CCR1、CCR2和/或CCR3介导的疾病的方法以及作为上述趋化因子受体的竞争性受体拮抗剂的鉴定测定中的对照物中是有用的。
• [EN] N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTI-VIRAL USES RELATED THERETO<br/>[FR] N4-HYDROXYCYTIDINE, SES DÉRIVÉS ET UTILISATIONS ANTI-VIRALES
  申请人：UNIV EMORY

  公开号：WO2016106050A1

  公开（公告）日：2016-06-30

  This disclosure relates to N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment and prophylaxis of viral infections.

  这项披露涉及N4-羟基胞嘧啶衍生物、组合物以及相关方法。在某些实施方式中，该披露涉及治疗和预防病毒感染。

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