5,5'-亚甲基二水杨酸 | 122-25-8

• 物质功能分类: 化学试剂 - 有机试剂 - 芳香酸
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5,5'-亚甲基二水杨酸
• 中文别名: 5,5’-亚甲基二水杨酸；5,5"-亚甲基二水杨酸
• 英文名称: 5,5'-methylenedisalicylic acid
• 英文别名: 5,5'-methylenebis(2-hydroxybenzoic acid)；5,5’-methylenedisalicylic acid；5,5'-methylene-bis-salicylic acid；5-(3-carboxy-4-hydroxybenzyl)-2-hydroxybenzoic acid；3,3'-dicarboxy-4,4'-dihydroxydiphenylmethane；ST018515；MDSA；5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxybenzoic acid
• CAS: 122-25-8
• 化学式: C₁₅H₁₂O₆
• mdl: MFCD00016506
• 分子量: 288.257
• InChiKey: JWQFKVGACKJIAV-UHFFFAOYSA-N

物化性质

• 熔点：
  235-242 °C
• 沸点：
  350.49°C (rough estimate)
• 密度：
  1.2709 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.066
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 安全说明：
  S24/25
• 海关编码：
  2918290000
• 储存条件：
  存放条件：室温、密闭保存且置于干燥处。

SDS

Name:	5 5 -Methylenedisalicylic Acid 95% Material Safety Data Sheet
Synonym:	None Known
CAS:	122-25-8

Section 1 - Chemical Product MSDS Name:5 5 -Methylenedisalicylic Acid 95% Material Safety Data Sheet
Synonym:None Known

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
122-25-8	5,5'-Methylenedisalicylic Acid	95%	204-530-5

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

---

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 122-25-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystals
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 238 deg C (dec)
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Insoluble.
Specific Gravity/Density:
Molecular Formula: C15H12O6
Molecular Weight: 288.0804

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not currently available.
Conditions to Avoid:
Incompatible materials, dust generation.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 122-25-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
5,5'-Methylenedisalicylic Acid - Not listed by ACGIH, IARC, or NTP.

---

Section 12 - ECOLOGICAL INFORMATION

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 122-25-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 122-25-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 122-25-8 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  5,5'-亚甲基二水杨酸 生成 2-hydroxy-5-(4-hydroxy-benzyl)-benzoic acid
  参考文献：
  名称：

  Clemmensen; Heitman, Journal of the American Chemical Society, 1911, vol. 33, p. 740

  摘要：

  DOI：
• 作为产物：
  描述：

  dimethyl 5,5'-methylenebis(2-hydroxybenzoate) 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 生成 5,5'-亚甲基二水杨酸
  参考文献：
  名称：

  Methylenedisalicylic acid derivatives: New PTP1B inhibitors that confer resistance to diet-induced obesity

  摘要：

  Methylenedisalicylic acid derivatives were synthesized and their inhibitory activities against protein tyrosine phosphalases (PTPases) examined. Two of the compounds, 8 and 9, showed K-i values of 9.4 and 6.3 mu M against PTP I B, 4- and 7-fold lower values compared to those against TC-PTP. They were reversible and slow-binding inhibitors against PTP I B. When compound 8 was fed to a mouse model, the weight gain and adipocyte fat storage induced by a high-fat-diet were significantly suppressed. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.069

文献信息

• Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer
  申请人：——

  公开号：US20030229120A1

  公开（公告）日：2003-12-11

  Novel ligands for the HisB10 Zn 2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.

  揭示了能够延长胰岛素制剂作用的R-态胰岛素六聚体的HisB10 Zn2+位点的新配体。
• [EN] PHAMACEUTICAL PREPARATIONS COMPRISING INSULIN<br/>[FR] PREPARATIONS PHARMACEUTIQUES CONTENANT DE L'INSULINE
  申请人：NOVO NORDISK AS

  公开号：WO2006005683A1

  公开（公告）日：2006-01-19

  Novel preparations comprising ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer wherein the ligand is extended by protamine that are capable of prolonging the ac­tion of insulin preparations.

  新型制剂包括配体，用于R-态胰岛素六聚体的HisB10 Zn2+位点，其中配体通过精氨酸延长，能够延长胰岛素制剂的作用。
• Stabilised insulin compositions
  申请人：Kaarsholm Christian Niels

  公开号：US20050065066A1

  公开（公告）日：2005-03-24

  The present invention provides pharmaceutical compositions comprising insulin and novel ligands for the His B10 Zn 2+ sites of the R-state insulin hexamer. The resulting preparations have improved physical and chemical stability.

  本发明提供了包含胰岛素和新型配体的药物组合物，用于R-态胰岛素六聚体的His B10 Zn2+位点。由此制备的药物具有改善的物理和化学稳定性。
• Synthesis and<i>in vitro</i>study of novel bis-[3-(2-arylmethylidenimino-1,3-thiazol-4-yl)-4-hydroxy-<i>2H</i>-chromen-2-one-6-yl]methane and bis-[3-(2-arylidenhydrazo-1,3-thiazol-4-yl)-4-hydroxy-<i>2H</i>-chromen-2-one-6-yl]methane as potential antimicrobial agents
  作者：M. Raghu、A. Nagaraj、Ch. Sanjeeva Reddy

  DOI：10.1002/jhet.63

  日期：2009.3

  A series of novel bis-[3-(2-arylmethylidenimino-1,3-thiazol-4-yl)-4-hydroxy-2H-chromen-2-one-6-yl]methane and bis-[3-(2-arylidenhydrazo-1,3-thiazol-4-yl)-4-hydroxy-2H-chromen-2-one-6-yl]-methane were synthesized in good yields from bis-[3-(2-bromoacetyl-4-hydroxy-2H-chromen-2-one-6-yl]methane . The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H NMR, MS, and elemental

  一系列新颖的双-[3-（3-（2-芳基亚甲基亚氨基-1,3-噻唑-4-基）-4-羟基-2H-铬-2-（1-6）基]甲烷和双-[3-（2-（2-芳基肼基-1,3-噻唑-4-基）-4-羟基-2H-铬烯-2-一-6-基]-甲烷由双[3-（2-溴乙酰-4-羟基-2-羟基-2H-铬-2--2--6-基]甲烷合成，收率很高。通过IR，1 H NMR，MS和元素分析阐明了新合成化合物的化学结构。此外，筛选所有化合物对革兰氏阳性，革兰氏阴性细菌和真菌的抗微生物活性。在合成的化合物中，， ， 和 被发现对几乎所有测试细菌最活跃。化合物表现出对枯草芽孢杆菌（ATCC 6633），金黄色葡萄球菌（ATCC6538p），黄球菌（IFC 12708），变形杆菌（ATCC 3851）和鼠伤寒沙门氏菌（ATCC 14028）的显着抗菌活性氨苄青霉素。同样，这些化合物也显示出对强效的抗真菌作用白色念珠菌（ATCC 10231），烟曲霉（HIC
• [EN] PHARMACEUTICAL PREPARATIONS COMPRISING ACID-STABILISED INSULIN<br/>[FR] PREPARATIONS PHARMACEUTIQUES CONTENANT DE L'INSULINE STABILISEE D'UN POINT DE VUE ACIDE
  申请人：NOVO NORDISK AS

  公开号：WO2004080480A1

  公开（公告）日：2004-09-23

  Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.

  揭示了能够延长胰岛素制剂作用的R态胰岛素六聚体的HisB10 Zn2+位点的新配体。

表征谱图