N-[(2,4-dinitrophenyl)sulfonyl]phenylethylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(2,4-dinitrophenyl)sulfonyl]phenylethylamine
• 英文别名: N-(2-phenylethyl) 2,4-dinitrophenylsulfonamide；2,4-dinitro-N-phenethylbenzenesulfonamide；N-phenethyl-2,4-dinitrobenzenesulfonamide；2,4-dinitro-N-phenethyl-benzenesulfonamide；2,4-dinitro-N-(2-phenylethyl)benzenesulfonamide
• 化学式: C₁₄H₁₃N₃O₆S
• 分子量: 351.34
• InChiKey: ROEMDOIPCQJOCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  146
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-[(2,4-dinitrophenyl)sulfonyl]phenylethylamine 在 苯硫酚 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 以94%的产率得到2-苯乙胺
  参考文献：
  名称：

  2-Nitro- and 2,4-Dinitrobenzenesulfonamides as Protecting Groups for Primary Amines

  摘要：

  开发了 2-硝基-和 2,4-二硝基苯磺酰胺脱保护得到相应伯胺的程序。在温和条件下，通过 HSCH2CH2OH/DBU 或 PhSH/Cs2CO3 在 DMF 中有效去除 2-硝基苯磺酰基，以高至优异的收率得到相应的伯胺。为了去除 2,4-二硝基苯磺酰基，单独使用硫醇（HSCH2CH2OH 或 PhSH）非常有效。还实现了在2-硝基苯磺酰胺存在下选择性脱保护2,4-二硝基苯磺酰胺。

  DOI：

  10.1055/s-2001-15158
• 作为产物：
  描述：

  2,4-二硝基苯磺酰氯 、 2-苯乙胺 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以79%的产率得到N-[(2,4-dinitrophenyl)sulfonyl]phenylethylamine
  参考文献：
  名称：

  Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)

  摘要：

  Here, we synthesized and studied a library of 2,4-dinitrophenylsulfonamides that closely resembled N-benzyl-2,4-dinitrophenylsulfonamide (1), a thiol-activated prodrug of sulfur dioxide (SO2) which has shown high potency as a Mycobacterium tuberculosis (Mtb) inhibitory agent. The ability of these compounds to generate SO2 in the presence of a thiol was evaluated. A good correlation between pK(aH) of the corresponding amine and reactivity with thiols to generate SO2 was found suggesting that the rate determining step of SO2 generation involved protonation of the amine. Amongst analogues with measurable MICs, we also found a correlation between ability to generate SO2 and Mtb growth inhibitory activity. Together, we report several thiol-mediated prodrugs of SO2 which strongly inhibited Mtb growth (MIC < 1 mu g mL(-1)) with potential for further development as tuberculosis drug candidates. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.048

文献信息

• One-Pot Syntheses of Dissymmetric Diamides Based on the Chemistry of Cyclic Monothioanhydrides. Scope and Limitations and Application to the Synthesis of Glycodipeptides
  作者：David Crich、Kaname Sasaki、Md Yeajur Rahaman、Albert A. Bowers

  DOI：10.1021/jo900532e

  日期：2009.5.15

  protection of alcohols in the various reaction components. Reaction of N-benzyloxycarbonyl-l-aspartic monothioanhydride with unprotected glycosyl amines, followed by capture of the thioacid intermediate with N-sulfonyl amino acid derivatives results in a three-component convergent synthesis of glycosylated peptides.

  胺打开环状一硫代酸酐可方便地进入酰胺基硫代酸，酰胺基硫代酸可被2,4-二硝基苯磺酰胺，电子缺陷性叠氮化物或在桑格氏试剂存在下被胺原位捕获，在每种情况下均导致不对称的二酰胺一锅三分量的耦合顺序 单硫代马来酸酐和双官能亲核试剂（如氨基硫醇）的使用提供了杂环酰胺的使用。环状一硫代酸酐对醇的低反应性使得能够使用甲醇作为溶剂，并且消除了在各种反应组分中保护醇的需要。的反应Ñ苄氧基羰基升-天冬氨酸单硫代酸酐与未保护的糖基胺，然后用N-磺酰基氨基酸衍生物捕获硫酸中间体，导致糖基化肽的三组分收敛合成。
• S_N2-Type Nucleophilic Opening of β-Thiolactones (Thietan-2-ones) as a Source of Thioacids for Coupling Reactions
  作者：David Crich、Kasinath Sana

  DOI：10.1021/jo9001728

  日期：2009.5.1

  3-arylthiopropionamides carrying various substituents in the 2-position. Alternatively, the trapping combination of an electron deficient aryl halide and an amine may be replaced by a 2,4-dinitrobenzenesulfonamide, resulting in the formation of the same products overall with the incorporation of the latent amine in the sulfonamide into the final amide product. In another embodiment, the thiocarboxylate intermediate

  在3位上被烷基和氨基甲酰基单取代的β-硫内酯通过涉及S N的过程被芳硫醇盐进行亲核开环在4位上发生2型攻击，导致在3位上取代了3-芳基硫代丙酸酯。这些硫代羧酸盐可以通过亲山芳烃取代过程由Mukaiyama试剂或Sanger试剂原位捕获，从而导致高度活化的硫酯，然后使它们与伯胺或仲胺进一步反应，总体上导致一锅，三组分合成在2-位带有各种取代基的3-芳基硫代丙酰胺。或者，可用2,4-二硝基苯磺酰胺代替电子不足的芳基卤化物和胺的捕集组合，导致整体形成相同的产物，同时在磺酰胺中掺入潜伏胺到最终的酰胺产物中。在另一个实施例中，N-芳烃磺酰基3-芳基硫代丙酰胺衍生物。
• Thiomaleic Anhydride: A Convenient Building Block for the Synthesis of α-Substituted γ- and δ-Lactones through Free-Radical Addition, Nucleophilic Ring Opening, and Subsequent Thiocarboxylate Manipulation
  作者：David Crich、Md. Yeajur Rahaman

  DOI：10.1021/jo901219k

  日期：2009.9.4

  carbonates and carbamates undergo clean free-radical addition to thiomaleic anhydride to give substituted thiosuccinic anhydrides in high yield on treatment with tris(trimethylsilyl)silane and a radical initiator. After removal of the tert-butyloxycarbonyl group, cyclization then affords lactones or lactams substituted in the α-position by a thiocarboxylic acid residue. This group is converted to amides through

  在用三（三甲基甲硅烷基）硅烷和自由基引发剂处理后，碘代烷基叔丁基碳酸酯和氨基甲酸酯与硫代马来酸酐发生干净的自由基加成，以高产率得到取代的硫代琥珀酸酐。除去叔丁氧羰基后，环化得到在α-位被硫代羧酸残基取代的内酯或内酰胺。该基团通过与缺电子磺酰胺反应转化为酰胺，或通过衍生硫酯与苯硫酚、缺电子烯丙基苯基硫醚或苯基硼酸反应转化为醛和/或酮。
• THIOL MEDIATED/ACTIVATED PRODRUGS OF SULFUR DIOXIDE (SO2) HAVING ANTI-BACTERIAL ACTIVITY
  申请人：INDIAN INSTITUTE OF SCIENCE EDUCATION AN

  公开号：US20140121211A1

  公开（公告）日：2014-05-01

  Disclosed herein are thiol mediated/activated prodrugs of SO 2 , particularly 2,4-dinitrophenylsulfonamide analogues, having Formula-I or pharmaceutically acceptable salts thereof exhibiting tunable release profiles of SO 2 with significant therapeutic efficacy against bacterial infections. Further, the present invention provides pharmaceutical compositions comprising compound of Formula I or pharmaceutically acceptable salts thereof, along with pharmaceutically acceptable carriers/excipients.

  本文披露了硫醇介导/激活的SO2前药，尤其是2,4-二硝基苯磺酰胺类似物，具有公式I或其药学上可接受的盐，表现出可调节的SO2释放剖面，并对细菌感染具有显著的治疗功效。此外，本发明提供了包含公式I化合物或其药学上可接受的盐的制药组合物，以及药学上可接受的载体/赋形剂。
• Dihydro-3-(triphenylphosphoranylidene)-2,5-thiophendione: a convenient synthon for the preparation of substituted 1,4-thiazepin-5-ones and piperidinones via the intermediacy of thioacids
  作者：David Crich、Md. Yeajur Rahaman

  DOI：10.1016/j.tet.2010.04.002

  日期：2010.8

  Reaction of thiomaleic anhydride with triphenylphosphine gives the title compound, which undergoes reaction with a variety of aldehydes to give a range of alkylidene thiomaleic anhydrides (substituted monothioitaconic anhydrides). Subsequent treatment with tert-butoxycarbonylamino-substituted thiols, or under radical conditions with tert-butoxycarbonylamino-substituted alkyl halides results in a series of substituted monothiomaleic anhydrides, that on exposure to trifluoroacetic acid and then base lead to thiocarboxyl substituted 1,4-thiazepin-5-ones and piperidinones, respectively, that are ultimately trapped by reaction with 2,4-dinitrobenzenesulfonamides to give the corresponding amides. (C) 2010 Elsevier Ltd. All rights reserved.