N-环己基天冬氨酸 | 90979-36-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-环己基天冬氨酸
• 英文名称: N-cyclohexyl-L-aspartic acid
• 英文别名: (2S)-2-(Cyclohexylamino)butanedioic acid
• CAS: 90979-36-5
• 化学式: C₁₀H₁₇NO₄
• 分子量: 215.249
• InChiKey: ZFYIQPIHXRFFCZ-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  L-天门冬氨酸 、 环己酮 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 以11%的产率得到N-环己基天冬氨酸
  参考文献：
  名称：

  使用两个CN裂解酶生产N-环烷基取代的L-天冬氨酸的生物催化对映选择性氢化胺化反应

  摘要：

  N环烷基取代的氨基酸在制药和营养保健领域具有广泛的应用。在这里我们报告了使用乙二胺N，N'-二琥珀酸裂解酶（EDDS裂解酶）和以前设计的甲基天门冬氨酸氨裂解酶（MAL-Q73A）变体作为生物催化剂的各种N-环烷基取代的l-天冬氨酸的不对称合成。特别地，EDDS裂解酶显示出广泛的非天然底物混杂性和出色的对映选择性，允许将均烷基和杂环烷基胺（包括四元，五元和六元环）选择性加成富马酸酯，得到相应的N环烷基取代的lee> 99％的天冬氨酸这种生物催化方法为制备困难的N-环烷基取代的氨基酸提供了另一种合成选择。由于胺的范围很广，EDDS裂解酶是一种功能强大的合成工具，可以很好地补充迅速增长的生物催化剂工具箱，用于非规范氨基酸的不对称合成。

  DOI：

  10.1002/adsc.201801569

文献信息

• Compositions and methods for treatment of neoplastic disease
  申请人：——

  公开号：US20020177551A1

  公开（公告）日：2002-11-28

  The present invention comprises compositions and methods for treating a tumor or neoplastic disease in a host, The methods employ conjugates comprising superantigen polypeptides, nucleic acids with other structures that preferentially bind to tumor cells and are capable of inducing apoptosis. Also provided are superantigen-glycolipid conjugates and vesicles that are loaded onto antigen presenting cells to activate both T cells and NKT cells. Cell-based vaccines comprise tumor cells engineered to express a superantigen along with glycolipids products which, when expressed, render the cells capable of eliciting an effective anti-tumor immune response in a mammal into which these cells are introduced. Included among these compositions are tumor cells, hybrid cells of tumor cells and accessory cells, preferably dendritic cells. Also provided are tumoricidal T cells and NKT cells devoid of inhitory receptors or inhibitory signaling motifs which are hyperresponsive to the the above compositions and lipid-based tumor associated antigens that can be administered for adoptive immunotherapy of cancer and infectious diseases.

  本发明涉及一种用于治疗宿主体内肿瘤或肿瘤性疾病的组合物和方法。该方法采用包含超抗原多肽、具有其他结构的核酸和优先结合于肿瘤细胞并能够诱导细胞凋亡的结构的共轭物。还提供了超抗原-糖脂共轭物和负载于抗原呈递细胞上的囊泡，以激活T细胞和NKT细胞。基于细胞的疫苗包括肿瘤细胞，这些肿瘤细胞被改造以表达超抗原和糖脂产物，当这些细胞被引入哺乳动物体内时，这些细胞能够引起有效的抗肿瘤免疫反应。这些组合物包括肿瘤细胞、肿瘤细胞和辅助细胞的杂交细胞，优选为树突状细胞。还提供了无抑制性受体或抑制性信号基序的肿瘤细胞杀伤T细胞和NKT细胞，这些细胞对上述组合物和基于脂质的肿瘤相关抗原具有高度反应性，可用于癌症和传染病的免疫治疗。
• Compositions and Methods for Treatment of Neoplastic Disease
  申请人：Terman David S.

  公开号：US20110059901A1

  公开（公告）日：2011-03-10

  The present invention comprises compositions and methods for treating a tumor or neoplastic disease in a host, The methods employ conjugates comprising superantigen polypeptides or nucleic acids with other structures that preferentially bind to tumor cells and are capable of inducing apoptosis. Also provided are superantigen-glycolipid conjugates and vesicles that are loaded onto antigen presenting cells to activate both T cells and NKT cells. Cell-based vaccines comprise tumor cells engineered to express a superantigen along with glycolipids products which, when expressed, render the cells capable of eliciting an effective anti-tumor immune response in a mammal into which these cells are introduced. Included among these compositions are tumor cells, hybrid cells of tumor cells and accessory cells, preferably dendritic cells. Also provided are T cells and NKT cells activated by the above compositions that can be administered for adoptive immunotherapy.