1-(4-methoxyphenyl) 2-iminohydantoin | 1414382-24-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(4-methoxyphenyl) 2-iminohydantoin
• 英文别名: 2-amino-3-(4-methoxyphenyl)-4H-imidazol-5-one
• CAS: 1414382-24-3
• 化学式: C₁₀H₁₁N₃O₂
• 分子量: 205.216
• InChiKey: RMKUGGAZVOADOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(4-methoxyphenyl)cyanamide 在 ammonium hydroxide 、 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 0.5h， 生成 1-(4-methoxyphenyl) 2-iminohydantoin
  参考文献：
  名称：

  Novel and green protocol for the synthesis of 2-iminohydantoins

  摘要：

  A novel and green protocol for the synthesis of N-1 and C-5 substituted 2-iminohydantoins has been developed. Methyl N-cyano-N-alkyl/aryl-aminoacetate reacts with aqueous ammonia at room temperature in 10-30 min. The developed protocol does not require any work-up for the isolation or purification of the products; simple filtration can lead to the pure products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.057

文献信息

• Novel and green protocol for the synthesis of 2-iminohydantoins
  作者：Vinod Kumar、Hemlata Rana、M.P. Kaushik

  DOI：10.1016/j.tetlet.2012.09.057

  日期：2012.11

  A novel and green protocol for the synthesis of N-1 and C-5 substituted 2-iminohydantoins has been developed. Methyl N-cyano-N-alkyl/aryl-aminoacetate reacts with aqueous ammonia at room temperature in 10-30 min. The developed protocol does not require any work-up for the isolation or purification of the products; simple filtration can lead to the pure products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.