1,3-bis(2,6-dimethyl-3,5-dimethoxylcarbonyl-1,4-dihydropyridin-4-yl)benzene | 115951-99-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,3-bis(2,6-dimethyl-3,5-dimethoxylcarbonyl-1,4-dihydropyridin-4-yl)benzene
• 英文别名: Dimethyl 4-[3-[3,5-bis(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 115951-99-0
• 化学式: C₂₈H₃₂N₂O₈
• 分子量: 524.571
• InChiKey: IQBNYSRMNHGXFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  间苯二甲醛 、 乙酰乙酸甲酯 在 乙酸铵 、 溶剂黄146 作用下， 以70%的产率得到1,3-bis(2,6-dimethyl-3,5-dimethoxylcarbonyl-1,4-dihydropyridin-4-yl)benzene
  参考文献：
  名称：

  双1,4-二氢吡啶衍生物的合成

  摘要：

  摘要 通过对苯二醛或间苯二醛与活性亚甲基化合物反应合成了一系列双1,4-二氢吡啶衍生物。

  DOI：

  10.1081/scc-200054183

文献信息

• New potential calcium channel modulators: design and synthesis of compounds containing two pyridine, pyrimidine, pyridone, quinoline and acridine units under microwave irradiation
  作者：Shujiang Tu、Chunbao Miao、Fang Fang、Feng Youjian、Tuanjie Li、Qiya Zhuang、Xiaojing Zhang、Songlei Zhu、Daqing Shi

  DOI：10.1016/j.bmcl.2003.12.092

  日期：2004.3

  The synthesis of bifunctional pyridine, pyrimidine, pyridone, quinoline and acridine derivatives was investigated using dialdehyde as a precursor. A rapid and efficient method was developed for the synthesis of a range of bifunctional monocyclic, bicyclic and tricyclic products related to 1,4-DHPs with the aim of finding new classes of biologically active compounds.

  以二醛为前驱体研究了双功能吡啶，嘧啶，吡啶酮，喹啉和a啶衍生物的合成。为了发现新型的生物活性化合物，开发了一种快速有效的方法来合成一系列与1,4-DHPs有关的双功能单环，双环和三环产品。
• Synthesis of Bis‐1,4‐Dihydropyridine Derivatives
  作者：Songlei Zhu、Shujang Tu、Yuan Gao、Chunbao Miao、Tuanjie Li、Xiaojing Zhang、Fang Fang、Daqing Shi

  DOI：10.1081/scc-200054183

  日期：2005.4.1

  Abstract A series of bis‐1,4‐dihydropyridine derivatives were synthesized by the reaction of p‐phenylenedialdehyde or m‐phenylenedialdehyde and active methylene compounds.

  摘要 通过对苯二醛或间苯二醛与活性亚甲基化合物反应合成了一系列双1,4-二氢吡啶衍生物。
• Balboni; Valenti; Da Re, Pharmazie, 1988, vol. 43, # 5, p. 318 - 320
  作者：Balboni、Valenti、Da Re、Rovati、Makovec

  DOI：——

  日期：——
• Nano aluminium nitride as a solid source of ammonia for the preparation of hantzsch 1,4-dihydropyridines and bis-(1,4-dihydropyridines) in water via one pot multicomponent reaction
  作者：Arash Ghorbani-Choghamarani、Mohammad Ali Zolfigol、Maryam Hajjami、Hamid Goudarziafshar、Mohsen Nikoorazm、Somaieh Yousefi、Bahman Tahmasbi

  DOI：10.1590/s0103-50532011000300016

  日期：——

  Nano aluminium nitride in the presence of water acts as solid source of ammonia, which is used for the preparation of 1,4-dihydropyridines and bis-(1,4-dihydropyridines). An efficient and simple procedure for the one-pot synthesis of 1,4-dihydropyridine and bis-(1,4-dihydropyridine) derivatives was achieved by combination of methyl acetoacetate or ethyl acetoacetate with aldehydes or dialdehydes and aluminium nitride at 80 degrees C in water in high purity and good yields.