nijmegen 1 | 159155-03-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: nijmegen 1
• 英文别名: Nijmegen-1；methyl (Z)-2-(1,3-dioxoisoindol-2-yl)-3-[(4-methyl-5-oxo-2H-furan-2-yl)oxy]prop-2-enoate
• CAS: 159155-03-0
• 化学式: C₁₇H₁₃NO₇
• 分子量: 343.293
• InChiKey: UBVNIMAEIBGUEL-WQLSENKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  99.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  nijmegen 1 在 二苯甲酮 作用下， 以 甲苯 为溶剂， 以35%的产率得到(E)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(4-methyl-5-oxo-2,5-dihydro-furan-2-yloxy)-acrylic acid methyl ester
  参考文献：
  名称：

  Thuring, Jan Willem J. F.; Van Gaal, Angelique A. M. A.; Hornes, Sander J., Journal of the Chemical Society. Perkin transactions I, 1997, # 5, p. 767 - 774

  摘要：

  DOI：
• 作为产物：
  描述：

  2-邻苯二甲酰亚胺基乙酸甲酯 在 potassium tert-butylate 、 sodium 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 nijmegen 1
  参考文献：
  名称：

  Synthesis of a Phthaloylglycine-Derived Strigol Analogue and Its Germination Stimulatory Activity toward Seeds of the Parasitic Weeds Striga hermonthica and Orobanche crenata

  摘要：

  The newly designed strigol analogue Nijmegen 1 (rac 7) was prepared in high overall yield starting from N-phthaloylglycine, This relatively simple analogue exhibits high bioactivity in the stimulation of germination of seeds of the parasitic weeds Striga hermonthica and Orobanche crenata. Nijmegen 1 was resolved in its enantiomers 7 and ent 7 by using the homochiral latent D-rings ent 11 and ent 12. The enantiomers 7 and ent 7 show significant differences in germination activity.

  DOI：

  10.1021/jf9604504

文献信息

• Modulators of the Development of Mychorrizal Fungi with Arbuscules, and Uses Thereof
  申请人：Becard Guillaume

  公开号：US20080318773A1

  公开（公告）日：2008-12-25

  The identification of compounds, strigolactones, having the ability to stimulate the growth and/or development of arbuscular mycorrhizal fungi (AM fungi). Such compounds are, for example, the natural strigolactones strigol, alectrol, sorgolactone, orobanchol, or their synthetic analogs GR7, GR24, Nijmegen-1, demethylsorgolactone. New ways of developing an agriculture that is more respectful of the environment, and permits the implementation, on a small or large scale, of advanced mycorrhization techniques aimed at optimizing the production of fungic inoculum, the use of AM fungi in soils or cultivation substrates, and intensifying the symbiotic interaction between these microorganisms and cultivated plants.
• PESTICIDAL COMPOSITION COMPRISING A STRIGOLACTONE DERIVATIVE AND AN INSECTICIDE COMPOUND
  申请人：Hungenberg Heike

  公开号：US20100137373A1

  公开（公告）日：2010-06-03

  A composition comprising at least a strigolactone derivative (a) of general formula: and an insecticide compound (b) in a (a)/(b) weight ratio of from 1/1 to 1/10 13 ; A composition further comprising an additional fungicidal compound; A method for preventively or curatively combating the pests and diseases of crops and increasing their yield by using this composition.
• PESTICIDE COMPOSITION COMPRISING A STRIGOLACTONE DERIVATIVE AND A FUNGICIDE COMPOUND
  申请人：Suty-Heinze Anne

  公开号：US20100152270A1

  公开（公告）日：2010-06-17

  A composition comprising at least a strigolactone derivative (a) of general formula: and a fungicide compound (b) in a (a)/(b) weight ratio of from 1/1 to 1/10 14 ; a composition further comprising an additional fungicidal compound; a method for preventively or curatively combating the pests and diseases of crops and increasing their yield by using this composition.
• US8101171B2
  申请人：——

  公开号：US8101171B2

  公开（公告）日：2012-01-24
• US9131685B2
  申请人：——

  公开号：US9131685B2

  公开（公告）日：2015-09-15