3-(p-Chlorphenyl)-5-(p-methoxyphenyl)-1-phenylpyrazol | 27293-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(p-Chlorphenyl)-5-(p-methoxyphenyl)-1-phenylpyrazol
• 英文别名: 3-(4-chloro-phenyl)-5-(4-methoxy-phenyl)-1-phenyl-1H-pyrazole；3-(4-Chlorophenyl)-5-(4-methoxyphenyl)-1-phenylpyrazole
• CAS: 27293-98-7
• 化学式: C₂₂H₁₇ClN₂O
• 分子量: 360.843
• InChiKey: AJZBTGLRHCHPIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(4-chloro-phenyl)-5-(4-methoxy-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazole 在 双氧水 、 potassium iodide 作用下， 以 乙醇 、 水 为溶剂， 反应 0.33h， 以90%的产率得到3-(p-Chlorphenyl)-5-(p-methoxyphenyl)-1-phenylpyrazol
  参考文献：
  名称：

  从过氧化氢/酸/碘化钾或钠体系原位生成 I+ 芳化 1,3,5-三取代的 4,5-二氢-1H-吡唑

  摘要：

  Payame Noor University 化学系, 19395-4697 Tehran, IR of Iran 2011 年 7 月 4 日收到，2011 年 10 月 18 日接受 1,3,5-三取代-2-芳构化采用简单、绿色、经济的方案吡唑啉通过原位生成碘（I

  DOI：

  10.5012/bkcs.2011.32.12.4366

文献信息

• Metal-free oxidative dehydrogenation of imidazolines and pyrazolines using silica-adsorbed peroxymonosulfate under aprotic and almost neutral conditions
  作者：H. Adibi、A. R. Hajipour、H. Jafari

  DOI：10.1007/s10593-008-0112-7

  日期：2008.7

  Oxidative dehydrogenation of 1,3,5-trisubstituted pyrazolines and 2-substituted imidazolines to their corresponding pyrazoles and imidazoles is carried out effectively by treatment with benzyltriphenylphosphonium peroxymonosulfate as an oxidant silica-adsorbed under aprotic and almost neutral conditions.
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Sheridan Joseph M.

  公开号：US20140031547A1

  公开（公告）日：2014-01-30

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Electrophoretics Limited

  公开号：US20160354375A1

  公开（公告）日：2016-12-08

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
• Aromatization of 1,3,5-Trisubstituted of 4,5-Dihydro-1H-Pyrazoles by In-Situ Generation of I⁺from Hydrogen Peroxide/Acids/Iodide Potassium or Sodium Systems
  作者：Behrooz Maleki、Hojat Veisi

  DOI：10.5012/bkcs.2011.32.12.4366

  日期：2011.12.20

  Department of Chemistry, Payame Noor University, 19395-4697 Tehran, I.R. of IranReceived July 4, 2011, Accepted October 18, 2011A simple, green and cost-effective protocol was used for the aromatization of 1,3,5-trisubstituted-2-pyrazolinesto the corresponding pyrazoles by in situ generation of iodine (I

  Payame Noor University 化学系, 19395-4697 Tehran, IR of Iran 2011 年 7 月 4 日收到，2011 年 10 月 18 日接受 1,3,5-三取代-2-芳构化采用简单、绿色、经济的方案吡唑啉通过原位生成碘（I