3-[[5-Ethoxy-1-(2-fluorophenyl)pyrazole-3-carbonyl]amino]-3-(4-fluorophenyl)propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[[5-Ethoxy-1-(2-fluorophenyl)pyrazole-3-carbonyl]amino]-3-(4-fluorophenyl)propanoic acid
• 英文别名: 3-[[5-ethoxy-1-(2-fluorophenyl)pyrazole-3-carbonyl]amino]-3-(4-fluorophenyl)propanoic acid
• 化学式: C₂₁H₁₉F₂N₃O₄
• 分子量: 415.4
• InChiKey: AUHXRMIJWYQHJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  93.4
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PURIFICATION PROCESS FOR SEMICONDUCTING MONOMERS
  申请人：Li Yuning

  公开号：US20100121004A1

  公开（公告）日：2010-05-13

  Disclosed is a process for purifying monomers of Formula (II): wherein R 1 and R 2 are independently selected from alkyl, substituted alkyl, aryl, substituted aryl, alkoxy, substituted alkoxy, and halogen; and R′ is selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkoxy, substituted alkoxy, and halogen. After the monomer is synthesized, it is purified by column chromatography using neutral alumina and hexane as an eluent. The resulting product can also be further recrystallized using isopropanol, hexane, heptane, or toluene. Polymers formed from the purified monomer exhibit higher mobility and increased reproducibility of the mobility.
• [EN] USE OF SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AS PHARMACEUTICALS FOR PREVENTION/TREATMENT OF ATRIAL FIBRILLATION<br/>[FR] UTILISATION DE DÉRIVÉS SUBSTITUÉS DE L'ACIDE 3-HÉTÉROAROYLAMINO-PROPIONIQUE EN TANT QUE PRODUITS PHARMACEUTIQUES DESTINÉS À LA PRÉVENTION/AU TRAITEMENT DE LA FIBRILLATION AURICULAIRE
  申请人：SANOFI SA

  公开号：WO2014053533A1

  公开（公告）日：2014-04-10

  The present invention relates to the use of compounds of the formula (I) for the treatment/prevention of atrial fibrillation, wherein A, D, E, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims. They are inhibitors of the protease cathepsin A.