N-Pentyl-isocapronsaeureamid | 100535-36-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-Pentyl-isocapronsaeureamid
• 英文别名: 4-methyl-N-pentylpentanamide
• CAS: 100535-36-2
• 化学式: C₁₁H₂₃NO
• mdl: MFCD24388077
• 分子量: 185.31
• InChiKey: QNNGBKKDHOYCNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-Pentyl-isocapronsaeureamid 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 Pentyl-isohexyl-amin
  参考文献：
  名称：

  A Study of the Formation of Haloamines and Cyclic Amines by the Free Radical Chain Decomposition of N-Haloammonium Ions (Hofmann-Löffler Reaction)¹

  摘要：

  DOI：

  10.1021/ja01492a035
• 作为产物：
  描述：

  异己酰氯 、 1-氨基戊烷 以 正戊烷 为溶剂， 生成 N-Pentyl-isocapronsaeureamid
  参考文献：
  名称：

  A Study of the Formation of Haloamines and Cyclic Amines by the Free Radical Chain Decomposition of N-Haloammonium Ions (Hofmann-Löffler Reaction)¹

  摘要：

  DOI：

  10.1021/ja01492a035

文献信息

• [EN] MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS<br/>[FR] COMPOSÉS MACROCYCLIQUES POUR L'INHIBITION D'INHIBITEURS DE L'APOPTOSE
  申请人：ENSEMBLE THERAPEUTICS

  公开号：WO2013071035A1

  公开（公告）日：2013-05-16

  The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.

  这项发明通常涉及大环化合物及其治疗用途。更具体地，该发明涉及调节凋亡抑制蛋白（IAPs）活性的大环化合物和/或用于治疗癌症等医疗状况的化合物。
• CYCLOSPORIN CONJUGATES
  申请人：Selwood David

  公开号：US20120157385A1

  公开（公告）日：2012-06-21

  A conjugate which comprises a cyclosporin moiety of formula (I) linked to one or more mitochondrial targeting groups, or a pharmaceutically acceptable salt thereof: wherein: A represents or, B represents methyl or ethyl, one Of R 1 and R 1 represents hydrogen and the other represents methyl, R 2 represents ethyl or isopropyl, R 3 represents hydrogen or methyl, and R 4 represents —CH 2 CH(CH 3 )CH 3 , —CH 2 CH(CH 3 )CH 2 CH 3 , —CH(CH 3 )CH 3 or —CH(CH 3 )CH 2 CH 3 .
• MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas Operations, Inc.

  公开号：US20220402907A1

  公开（公告）日：2022-12-22

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Kirsten rat sarcoma protein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
• [EN] RADIOPHARMACEUTICAL CONJUGATES TARGETING GUANYLYL CYCLASE C, AND COMPOSITIONS AND USES THEREOF<br/>[FR] CONJUGUÉS RADIOPHARMACEUTIQUES CIBLANT LA GUANYLYLE CYCLASE C, ET COMPOSITIONS ET UTILISATIONS DE CEUX-CI
  申请人：[en]RAYZEBIO, INC.

  公开号：WO2022115799A1

  公开（公告）日：2022-06-02

  Provided herein are radiopharmaceutical conjugate compositions and uses thereof. In one aspect, provided herein are conjugates that comprise a GCC binding peptide, a metal chelator configured to bind with a radionuclide, a linker that attaches the GCC binding peptide with the metal chelator, and optionally a radionuclide. Also provided herein are conjugates that have improved elimination profile and plasma stability that are suitable for radiopharmaceutical applications and methods of using the same in treating and/or diagnosing diseases such as cancer.
• A Study of the Formation of Haloamines and Cyclic Amines by the Free Radical Chain Decomposition of N-Haloammonium Ions (Hofmann-Löffler Reaction)¹
  作者：E. J. Corey、Walter R. Hertler

  DOI：10.1021/ja01492a035

  日期：1960.4