SR 3677 dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: SR 3677 dihydrochloride
• 英文别名: N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide;dihydrochloride
• 化学式: C22H26Cl2N4O4
• 分子量: 481.4
• InChiKey: INVVXEKRUDMEBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.64
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  88.7
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• MEDIUM FOR CULTURING STEM CELLS, METHOD FOR CULTURING STEM CELLS, STEM CELL GROWTH PROMOTER, AND CELL COMPOSITION AND METHOD FOR PRODUCING SAME
  申请人：Kyowa Hakko Bio Co., Ltd.

  公开号：EP3511410A1

  公开（公告）日：2019-07-17

  An object of the present invention is to provide a technique for stably, inexpensively, and safely culturing stem cells having a differentiation ability while maintaining an undifferentiated state. The present invention relates to a medium for culturing stem cells, comprising at least one or more compounds selected from the group consisting of a ROCK inhibitor, a PKC inhibitor, a histone methyltransferase inhibitor, and a retinoic acid receptor agonist, and not containing a growth factor or having a low growth factor concentration; a method for culturing stem cells using the medium; a growth promoter for stem cell; as well as a cell composition containing stem cells or differentiated cells therefrom; and a method for producing the cell composition.

  本发明的目的是提供一种技术，稳定、廉价、安全地培养具有分化能力的干细胞，同时保持未分化状态。本发明涉及一种培养干细胞的培养基，该培养基包含至少一种或多种选自 ROCK 抑制剂、PKC 抑制剂、组蛋白甲基转移酶抑制剂和维甲酸受体激动剂的化合物，且不含生长因子或生长因子浓度较低；一种使用该培养基培养干细胞的方法；一种干细胞生长促进剂；以及一种含有干细胞或从中分化的细胞的细胞组合物；以及一种生产该细胞组合物的方法。
• MEDIUM FOR DIRECT DIFFERENTIATION OF PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELL, METHOD FOR PREPARING MESENCHYMAL STEM CELL BY USING SAME, AND MESENCHYMAL STEM CELL PREPARED THEREBY
  申请人：CHA Biotech Co., Ltd.

  公开号：EP3848455A1

  公开（公告）日：2021-07-14

  The present invention relates to a medium for direct differentiation of embryonic stem cell-derived mesenchymal stem cells, a method of preparing mesenchymal stem cells by using same, mesenchymal stem cells prepared thereby, and a cell therapy product comprising the same mesenchymal stem cells. In a medium composition and a method according to an embodiment, mesenchymal stem cells may be prepared at high yield within a short period of time. In addition, the method is simple in preparation procedure because of the absence of an embryoid body formation step and allows homogeneous cells to be prepared, thus advantageously providing a cell therapy product within a reduce period of time, compared to conventional methods.

  本发明涉及一种用于直接分化胚胎干细胞衍生间充质干细胞的培养基、使用该培养基制备间充质干细胞的方法、由此制备的间充质干细胞以及包含相同间充质干细胞的细胞治疗产品。根据一个实施方案中的培养基组合物和方法，间充质干细胞可在短时间内高产制备。此外，由于没有胚状体形成步骤，该方法制备程序简单，可制备均质细胞，因此与传统方法相比，可在较短时间内提供细胞治疗产品。
• Use of small molecules to enhance MAFA expression in pancreatic endocrine cells
  申请人：Janssen Biotech, Inc.

  公开号：US10006006B2

  公开（公告）日：2018-06-26

  The present invention provides methods, cell cultures and differentiation media to promote differentiation of pluripotent stem cells to pancreatic endocrine cells of a mature phenotype. The resulting pancreatic endocrine cells express single hormonal insulin, PDX1, NKX6.1, and MAFA. In one or more differentiation stages, culturing may be carried out in a culture vessel at the air-liquid interface.

  本发明提供了促进多能干细胞分化为成熟表型的胰腺内分泌细胞的方法、细胞培养物和分化培养基。由此产生的胰腺内分泌细胞表达单一激素胰岛素、PDX1、NKX6.1 和 MAFA。在一个或多个分化阶段，可在空气-液体界面的培养容器中进行培养。
• Ex vivo proliferation of epithelial cells
  申请人：PROPAGENIX INC.

  公开号：US10119121B2

  公开（公告）日：2018-11-06

  The technology relates in part to methods and compositions for ex vivo proliferation and expansion of epithelial cells.

  该技术部分涉及上皮细胞体外增殖和扩增的方法和组合物。
• Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
  申请人：Janssen Biotech, Inc.

  公开号：US10344264B2

  公开（公告）日：2019-07-09

  The present invention provides methods, cell cultures and differentiation media to promote differentiation of pluripotent stem cells to pancreatic endocrine cells expressing PDX1, NKX6.1, and HB9 by culturing in a culture vessel at the air-liquid interface. The invention also provides for in vivo maturation of cells cultured at the air-liquid interface.

  本发明提供了通过在空气-液体界面的培养容器中培养，促进多能干细胞分化为表达PDX1、NKX6.1和HB9的胰腺内分泌细胞的方法、细胞培养物和分化培养基。本发明还提供了在气液界面培养的细胞的体内成熟。