4-(3-methoxy-4-methylphenyl)-1H-pyrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(3-methoxy-4-methylphenyl)-1H-pyrazole
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.23
• InChiKey: SRSYTRPJAQMDPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS
  申请人：AXFORD Jake

  公开号：US20140206661A1

  公开（公告）日：2014-07-24

  The present invention provides a compound of Formula (X) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种公式（X）的化合物或其药用盐；一种制造本发明化合物的方法及其治疗用途。本发明进一步提供了一种药物活性剂的组合物和一种药物组合物。
• RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF
  申请人：Beijing Tide Pharmaceutical Co., Ltd.

  公开号：EP3647311A1

  公开（公告）日：2020-05-06

  The present invention relates to a Rho-associated protein kinase inhibitor of formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and a use of the same in preventing or treating a disease mediated by Rho-associated protein kinase (ROCK).

  本发明涉及一种式（I）的Rho相关蛋白激酶抑制剂、一种包含其的药物组合物、其制备方法以及其在预防或治疗由Rho相关蛋白激酶（ROCK）介导的疾病中的用途。
• THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS
  申请人：Novartis AG

  公开号：EP3736271A1

  公开（公告）日：2020-11-11

  The present invention provides a compound of Formula (X) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种式（X）化合物或其药学上可接受的盐； 一种制造本发明化合物的方法及其治疗用途。本发明进一步提供了一种药理活性剂的组合物和一种药物组合物。
• Methods for modulating splicing
  申请人：Skyhawk Therapeutics, Inc.

  公开号：US11129829B2

  公开（公告）日：2021-09-28

  Described herein are methods of use of small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.

  本文描述了小分子剪接调节剂化合物的使用方法，这些化合物可调节基因编码的 mRNA（如前 mRNA）的剪接，以及治疗与基因表达或基因编码的蛋白质活性相关的疾病和病症的方法。
• Methods and compositions for modulating splicing
  申请人：SKYHAWK THERAPEUTICS, INC.

  公开号：US11162101B2

  公开（公告）日：2021-11-02

  Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

  本文描述了可调节基因编码的 mRNA（如 pre-mRNA）剪接的小分子剪接调节剂化合物，以及使用小分子剪接调节剂化合物调节剪接和治疗疾病的方法。