(2S)-2-[[1-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)-3-[4-[[4-(dimethylamino)phenyl]diazenyl]phenyl]-1,3-dioxopropan-2-yl]amino]hexanamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (2S)-2-[[1-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)-3-[4-[[4-(dimethylamino)phenyl]diazenyl]phenyl]-1,3-dioxopropan-2-yl]amino]hexanamide
• 化学式: C₄₃H₃₉N₅O₈
• 分子量: 753.8
• InChiKey: RORRINASXWPVRU-VYXSRHMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  56
• 可旋转键数：
  13
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  193
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• METHODS FOR DETECTION OF BOTULINUM NEUROTOXIN
  申请人：CITY OF HOPE

  公开号：US20140235490A1

  公开（公告）日：2014-08-21

  Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin. This assay is designed to capture a low number of toxin molecules and to measure their intrinsic protease activity via conversion of a fluorogenic or luminescent substrate. Also provided herein are novel peptides that can be specifically cleaved by BoNT and novel peptides that are resistant to cleavage by BoNT. The combination of these cleavable and control peptides can be used for implementation of an exemplary ALISSA used to specifically detect BoNT enzymatic activity. Furthermore, the ALISSA as described herein may also be used in a column based format for use in a high-throughput system for testing large quantities of samples.
• US9562903B2
  申请人：——

  公开号：US9562903B2

  公开（公告）日：2017-02-07