Methyl 4-[3-[4-[[2-[[3-[[2-[(5-ethoxy-5-oxopent-1-en-2-yl)-methylamino]ethyl-propylamino]methyl]benzoyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonyl]amino]phenyl]propyl]benzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: Methyl 4-[3-[4-[[2-[[3-[[2-[(5-ethoxy-5-oxopent-1-en-2-yl)-methylamino]ethyl-propylamino]methyl]benzoyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonyl]amino]phenyl]propyl]benzoate
• 英文别名: methyl 4-[3-[4-[[2-[[3-[[2-[(5-ethoxy-5-oxopent-1-en-2-yl)-methylamino]ethyl-propylamino]methyl]benzoyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonyl]amino]phenyl]propyl]benzoate
• 化学式: C₄₇H₅₈N₄O₆S
• 分子量: 807.1
• InChiKey: VGIOPQMXQQMFOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  58
• 可旋转键数：
  23
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• AMINOALKYL-SUBSTITUTED N-THIENYL BENZAMIDE DERIVATIVE
  申请人：Astellas Pharma Inc.

  公开号：EP2772490A1

  公开（公告）日：2014-09-03

  [Problem] To provide a compound that has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. [Means for Solution] The present inventors conducted thier studies on a compound that has an NPT-IIb inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. As a result, they created an aminoalkyl-substituted N-thienylbenzamide derivative which has NPT-IIb inhibitory action, thereby completing the present invention. The aminoalkyl-substituted N-thienylbenzamide derivative of the present invention has an NPT-IIb inhibitory action and can be used as an agent for preventing and/or treating hyperphosphatemia.

  [问题]提供一种化合物，该化合物具有抑制肠磷酸盐转运体（NPT-IIb）的作用，并可作为治疗和/或预防高磷酸盐血症的药物的活性成分。 [解决方法]本发明者对一种化合物进行了研究，该化合物具有 NPT-IIb 抑制作用，可作为治疗和/或预防高磷酸盐血症药物的活性成分。结果，他们创造了一种具有 NPT-IIb 抑制作用的氨基烷基取代的 N-噻吩基苯甲酰胺衍生物，从而完成了本发明。本发明的氨基烷基取代的 N-噻吩基苯甲酰胺衍生物具有 NPT-IIb 抑制作用，可用作预防和/或治疗高磷酸盐血症的药物。