N-hydroxy-4-[5-[2-methyl-5-(1H-pyrazol-5-yl)phenyl]-3-(trifluoromethyl)pyrazol-1-yl]benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-hydroxy-4-[5-[2-methyl-5-(1H-pyrazol-5-yl)phenyl]-3-(trifluoromethyl)pyrazol-1-yl]benzamide
• 化学式: C₂₁H₁₆F₃N₅O₂
• 分子量: 427.386
• InChiKey: CINLDZPUVMSAHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  95.8
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：TRANSLATIONAL DRUG DEVELOPMENT, LLC

  公开号：US20160009702A1

  公开（公告）日：2016-01-14

  The present invention comprises compounds of Formula I and their use in the inhibition of cell proliferation in therapeutic treatments. Pharmaceutical compositions comprising at least one compound of Formula I and at least one pharmaceutical excipient are disclosed, as well as methods of using compounds of Formula I and pharmaceutical compositions thereof for treatment of hyper-proliferative diseases and other disorders.

  本发明涉及式I化合物及其在治疗中抑制细胞增殖方面的使用。本发明公开了包括至少一种式I化合物和至少一种药用辅料的制药组合物，以及使用式I化合物和其制药组合物治疗高增殖性疾病和其他疾病的方法。
• [EN] PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS PYRAZOLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：TRANSLATIONAL DRUG DEV LLC

  公开号：WO2014138616A2

  公开（公告）日：2014-09-12

  The present invention comprises compounds of Formula I and their use in the inhibition of cell proliferation in therapeutic treatments. Pharmaceutical compositions comprising at least one compound of Formula I and at least one pharmaceutical excipient are disclosed, as well as methods of using compounds of Formula I and pharmaceutical compositions thereof for treatment of hyper-proliferative diseases and other disorders.