5-(1,2-Oxazol-3-yl)-2-(3,3,3-trifluoropropyl)pyrazole-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(1,2-Oxazol-3-yl)-2-(3,3,3-trifluoropropyl)pyrazole-3-carboxylic acid
• 英文别名: 5-(1,2-oxazol-3-yl)-2-(3,3,3-trifluoropropyl)pyrazole-3-carboxylic acid
• 化学式: C₁₀H₈F₃N₃O₃
• 分子量: 275.18
• InChiKey: DIEDPPVSQPRRET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  81.2
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] PYRAZOLE DERIVATIVES AS SGC STIMULATORS<br/>[FR] DÉRIVÉS DE PYRAZOLE UTILISÉS COMME STIMULATEURS DE SGC
  申请人：IRONWOOD PHARMACEUTICALS INC

  公开号：WO2016044447A1

  公开（公告）日：2016-03-24

  There are described imidazole and pyrazole derivatives which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

  描述了咪唑和吡唑衍生物，它们可作为sGC的刺激剂，特别是NO独立、依赖血红素的刺激剂。这些化合物还可用于治疗、预防或管理本文中披露的各种疾病。
• SGC STIMULATORS
  申请人：Ironwood Pharmaceuticals, Inc.

  公开号：EP2970243A2

  公开（公告）日：2016-01-20
• PYRAZOLE DERIVATIVES AS SGC STIMULATORS
  申请人：Ironwood Pharmaceuticals, Inc.

  公开号：EP3194382A1

  公开（公告）日：2017-07-26
• [EN] SGC STIMULATORS<br/>[FR] STIMULATEURS DE SGC
  申请人：NAKAI TAKASHI

  公开号：WO2014144100A2

  公开（公告）日：2014-09-18

  Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.