[[(1S,3S,4S)-4-[(1R,4R,5R,8R)-2,8-dimethyl-9-methylidene-3-oxatricyclo[6.3.0.01,4]undecan-5-yl]-3-(2-imidazol-1-ylethyl)-4-methylcyclohexyl]oxy-lambda4-sulfanylidyne]phosphane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [[(1S,3S,4S)-4-[(1R,4R,5R,8R)-2,8-dimethyl-9-methylidene-3-oxatricyclo[6.3.0.01,4]undecan-5-yl]-3-(2-imidazol-1-ylethyl)-4-methylcyclohexyl]oxy-lambda4-sulfanylidyne]phosphane
• 英文别名: [[(1S,3S,4S)-4-[(1R,4R,5R,8R)-2,8-dimethyl-9-methylidene-3-oxatricyclo[6.3.0.01,4]undecan-5-yl]-3-(2-imidazol-1-ylethyl)-4-methylcyclohexyl]oxy-λ4-sulfanylidyne]phosphane
• 化学式: C₂₅H₃₇N₂O₂PS
• 分子量: 460.6
• InChiKey: YSZMIKWACXLJNO-HUJCQYEGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  37.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] SHIP1 MODULATORS AND METHODS RELATED THERETO<br/>[FR] MODULATEURS DE SHIP1 ET MÉTHODES ASSOCIÉES
  申请人：AQUINOX PHARMACEUTICALS INC

  公开号：WO2014143561A1

  公开（公告）日：2014-09-18

  Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

  式（I）的化合物：其中R1、R2、R3、R4a、R4b、R5、R6和R7如本文所定义，或其立体异构体或药学上可接受的盐，在本文中有描述。这些化合物具有SHIP1调节剂的活性，因此可用于治疗任何需要SHIP1调节的各种疾病、疾病或病况。还公开了包含式（I）化合物与药学上可接受的载体或稀释剂组合的组合物，以及通过向需要的动物施用这些化合物来进行SHIP1调节的方法。