(Z)-2-hydroxy-3-phenyl-1-(2,3,4-trihydroxyphenyl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (Z)-2-hydroxy-3-phenyl-1-(2,3,4-trihydroxyphenyl)prop-2-en-1-one
• 化学式: C₁₅H₁₂O₅
• 分子量: 272.25
• InChiKey: MHUPRUAVVBJHGS-WQLSENKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Sirtuin polymorphisms and methods of use thereof
  申请人：Laakso Markku

  公开号：US20080249103A1

  公开（公告）日：2008-10-09

  Provided herein are methods for diagnosis and prognosis using polymorphic variants of sirtuins. Such polymorphic may be used, for example, to identify subjects that would be responsive to treatment with a sirtuin modulating compound and/or subjects that are suffering from or susceptible to a disease mediated by a sirtuin. Also provided are methods for determining the predictive value of a sirtuin polymorphic variant, methods for evaluating sirtuin modulating compounds, and methods for determining appropriate dosage and/or treatment regimens for subjects having one or more sirtuin polymorphic variants. Screening methods for identifying sirtuin modulating compounds using polymorphic variants of a sirtuin are also provided.

  本文提供了使用sirtuins的多态性变体进行诊断和预后的方法。这种多态性可能被用来识别对sirtuin调节化合物治疗有响应的受试者，以及患有或易受sirtuin介导疾病影响的受试者。还提供了确定sirtuin多态性变体预测价值的方法，评估sirtuin调节化合物的方法，以及确定具有一个或多个sirtuin多态性变体的受试者的适当剂量和/或治疗方案的方法。还提供了使用sirtuin的多态性变体筛选识别sirtuin调节化合物的筛选方法。
• BIOMARKERS OF SIRTUIN ACTIVITY AND METHODS OF USE THEREOF
  申请人：Boss Olivier

  公开号：US20100215632A1

  公开（公告）日：2010-08-26

  Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods for identifying compounds that modulate the activity of a sirtuin protein using one or more sirtuin biomarkers.

  提供了一种监测主体中sirtuin调节的方法，例如，在使用sirtuin调节化合物进行治疗期间。该方法涉及确定来自主体生物样本中一个或多个sirtuin生物标志物的表达水平。还提供了一种使用一个或多个sirtuin生物标志物识别调节sirtuin蛋白活性的化合物的方法。
• Compositions for manipulating the lifespan and stress response of cells and organisms
  申请人：Sinclair A. David

  公开号：US20050096256A1

  公开（公告）日：2005-05-05

  Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.

  本文提供了调节sirtuin脱乙酰化酶蛋白家族成员、p53活性、细胞和生物的凋亡、寿命和对压力的敏感性的方法和组合物。示例方法包括将激活化合物（如黄酮类、stilbene、黄烷酮、异黄酮、儿茶素、查尔酮、单宁或花青素）或抑制化合物（如鞘脂类，例如鞘氨醇）与细胞接触。
• Production of flavonoids by recombinant microorganisms
  申请人：Koffas Mattheos

  公开号：US20060019334A1

  公开（公告）日：2006-01-26

  Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosymthetic pathway for the conversion of phenylpropanoids to various flavonoids. The method comprises the steps of introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes. When specific substrate(s) is/are provided to the transformed cell, the enzymes act on the substrate(s) to produce the desired flavonoids.

  本发明提供了一种在微生物宿主中生产黄酮类化合物的方法和组合物。该组合物包括一组基因，这些基因编码参与苯丙烷类物质转化为各种黄酮类化合物生物合成途径中的酶。该方法包括将该基因组引入异源宿主细胞中，让细胞在适宜培养基中生长，使得基因的表达导致酶的产生。当将特定底物提供给转化后的细胞时，酶作用于底物以产生所需的黄酮类化合物。
• Gene encoding a protein having aurone synthesis activity
  申请人：Sakakibara Keiko

  公开号：US20060020123A1

  公开（公告）日：2006-01-26

  The present invention provides a protein having aurone synthase activity involved in the color of flowers such as snapdragons, a gene that encodes it, cDNA in particular, and its applications. This gene can give yellow color to the flowers of plants by introducing into plants deficient in chalcone isomerase and so forth and expressing.

  本发明提供了一种具有花色素合酶活性的蛋白质，参与了如金鱼草等花卉的颜色，以及编码它的基因，特别是cDNA，以及其应用。该基因可以通过将其引入缺乏某些黄酮异构酶等植物中并表达来使植物的花朵呈现黄色。