RKI 1447 dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: RKI 1447 dihydrochloride
• 英文别名: 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea;dihydrochloride
• 化学式: C16H16Cl2N4O2S
• 分子量: 399.3
• InChiKey: GBXLRAPHQIRDNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.08
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  115
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• PLATELET PRODUCTION METHOD, PLATELET PREPARATION PRODUCTION METHOD, AND BLOOD PREPARATION PRODUCTION METHOD
  申请人：Megakaryon Corporation

  公开号：EP3680325A1

  公开（公告）日：2020-07-15

  The present invention provides a method for producing platelets that can improve at least one of the ability of megakaryocyte to produce platelets and the bioactivity of platelets produced even in high-density culture, for example. The method for producing platelets of the present invention includes a platelet producing step of producing platelets from megakaryocytes, wherein the platelet producing step is performed in the presence of at least one of glycine and cysteine.

  本发明提供了一种生产血小板的方法，该方法可以提高巨核细胞生产血小板的能力以及即使在高密度培养中生产的血小板的生物活性中的至少一项。本发明的血小板生产方法包括从巨核细胞生产血小板的步骤，其中血小板生产步骤是在甘氨酸和半胱氨酸中至少一种存在的情况下进行的。
• Methods for generating stem cell-derived beta cells and methods of use thereof
  申请人：President and Fellows of Harvard College

  公开号：US10253298B2

  公开（公告）日：2019-04-09

  Disclosed herein are methods for generating SC-β cells, and isolated populations of SC-β cells for use in various applications, such as cell therapy.

  本文公开了用于各种应用（如细胞疗法）的 SC-β 细胞生成方法和分离的 SC-β 细胞群。
• Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
  申请人：President and Fellows of Harvard College

  公开号：US10443042B2

  公开（公告）日：2019-10-15

  Disclosed herein are methods for generating SC-β cells using chemically defined, completely serum free media, and isolated populations of SC-β cells for use in various applications, such as cell therapy.

  本文公开了使用化学定义的完全无血清培养基生成 SC-β 细胞的方法，以及用于各种应用（如细胞疗法）的分离 SC-β 细胞群。
• A SUBSTRATE AND METHOD FOR THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS
  申请人：The Queen's University Of Belfast

  公开号：EP3630953A1

  公开（公告）日：2020-04-08
• METHOD OF PRODUCING ENTERIC NEURONS AND USES THEREOF
  申请人：The Regents of the University of California

  公开号：EP3898952A1

  公开（公告）日：2021-10-27