4-(6-(cyclohexylamino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile | 1012345-05-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(6-(cyclohexylamino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile
• 英文别名: 4-[6-(cyclohexylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
• CAS: 1012345-05-9
• 化学式: C₁₉H₁₉N₅
• 分子量: 317.393
• InChiKey: DJWHAISGEPYECC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(6-chloroimidazo[1,2-b]pyridazin-3-yl)benzonitrile 、 环己胺 以 N-甲基吡咯烷酮 为溶剂， 反应 1.0h， 以47%的产率得到4-(6-(cyclohexylamino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile
  参考文献：
  名称：

  Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7

  摘要：

  A high-throughput screening campaign identified a number of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Further synthetic chemistry efforts enabled the preparation of a number of analogues with promising in vitro potencies. Although these compounds show likely broad spectrum inhibitory activity, they represent a useful starting point for further chemical optimisation. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.043

文献信息

• MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE
  申请人：Durand-Reville Thomas

  公开号：US20110021513A1

  公开（公告）日：2011-01-27

  The present invention relates to modulators of IRAK kinase and provides compositions comprising such modulators, as well as methods therewith for treating conditions or diseases mediated by or associated with IRAK kinase.

  本发明涉及IRAK激酶的调节剂，并提供包含这些调节剂的组合物，以及利用这些调节剂治疗由IRAK激酶介导或相关的疾病或病症的方法。
• IRAK MODULATORS FOR TREATING AN INFLAMMATORY CONDITION, CELL PROLIFERATIVE DISORDER, IMMUNE DISORDER
  申请人：Biogen Idec MA Inc.

  公开号：EP2063962A2

  公开（公告）日：2009-06-03
• [EN] MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE<br/>[FR] MODULATEURS DE LA KINASE ASSOCIÉE AU RÉCEPTEUR DE L'INTERLEUKINE-1
  申请人：BIOGEN IDEC INC

  公开号：WO2008030579A2

  公开（公告）日：2008-03-13

  [EN] The present invention relates to modulators of IRAK kinase and provides compositions comprising such modulators, as well as methods therewith for treating conditions or diseases mediated by or associated with IRAK kinase.
  [FR] La présente invention concerne des modulateurs de la kinase IRAK (Interleukin-1 Receptor-Associated Kinase) et des compositions comprenant de tels modulateurs, ainsi que des procédés permettant de traiter des affections ou des maladies induites par la kinase IRAK ou associées à la kinase IRAK.