N-(3-azido-2-oxochromen-7-yl)acetamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-(3-azido-2-oxochromen-7-yl)acetamide
• 化学式: C₁₁H₈N₄O₃
• 分子量: 244.21
• InChiKey: YJDFENYLNSGDNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  69.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(3-azido-2-oxochromen-7-yl)acetamide 、 4-二甲基氨基苯乙炔 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 、 tris((4-ethoxycarbonylmethyl)-[1,2,3]triazol-1-ylmethyl)amine 作用下， 以 乙醇 、 水 为溶剂， 以97%的产率得到
  参考文献：
  名称：

  Development of a novel fluorescent sensor to detect a specific range of pH

  摘要：

  A novel fluorescent sensor for monitoring the change of pH was developed, based on a structure containing two hydroxyl groups that are sequentially deprotonated as the pH is increased: the first deprotonation increases the fluorescence intensity and the second decreases it. Compared with most reported pH sensors that can detect only whether or not the pH is below or above a specific value, our sensor could detect a specific range of pH (centered on pH 8-9) that should be useful for the study of biological microenvironment. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.10.037
• 作为产物：
  描述：

  tert-butyl N-[3-hydroxy-4-(hydroxymethyl)phenyl]carbamate 在 吡啶 、 4-二甲氨基吡啶 、 manganese(IV) oxide 、 草酰氯 、 三氟乙酸 、 2,8,9-三异丙基-2,5,8,9-四硫唑嘌呤-1-磷杂二环[3.3.3]十一烷 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 29.0h， 生成 N-(3-azido-2-oxochromen-7-yl)acetamide
  参考文献：
  名称：

  Development of a novel fluorescent sensor to detect a specific range of pH

  摘要：

  A novel fluorescent sensor for monitoring the change of pH was developed, based on a structure containing two hydroxyl groups that are sequentially deprotonated as the pH is increased: the first deprotonation increases the fluorescence intensity and the second decreases it. Compared with most reported pH sensors that can detect only whether or not the pH is below or above a specific value, our sensor could detect a specific range of pH (centered on pH 8-9) that should be useful for the study of biological microenvironment. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.10.037

文献信息

• Chemoselective Fluorgenic Molecular Linkers and Methods for Their Preparation and Use
  申请人：Wang Qian

  公开号：US20070224695A1

  公开（公告）日：2007-09-27

  The present invention describes a bioconjugation strategy and compounds that are useful therein in which a fluorescent signal is produced when two molecular or supramolecular entities are linked by chemoselective combination of one linker having an azido or halide substituent group with another linker having a cyano or an alkyne substituent group. A kit is also provided.

  本发明描述了一种生物共轭策略和在其中有用的化合物，当两个分子或超分子实体通过一个含有偶氮基或卤素取代基的连接剂与另一个含有氰基或炔基取代基的连接剂进行化学选择性组合时，会产生荧光信号。同时还提供了一种试剂盒。
• US7745229B2
  申请人：——

  公开号：US7745229B2

  公开（公告）日：2010-06-29
• [EN] CHEMOSELECTIVE FLUOROGENIC MOLECULAR LINKERS AND METHODS OF THEIR PREPARATION AND USE<br/>[FR] LIEURS MOLECULAIRES FLUOROGENES CHIMIOSELECTIFS ET LEURS PROCEDES DE PREPARATION ET D'UTILISATION
  申请人：UNIV SOUTH CAROLINA

  公开号：WO2005103705A2

  公开（公告）日：2005-11-03

  The present invention describes a bioconjugation strategy and compounds that are useful therein in which a fluorescent signal is produced when two molecular or supramolecular entities are linked by chemoselective combination of one linker having an azido or halide substituent group with another linker having a cyano or an alkyne substituent group. A kit is also provided.