(4R,5S,6S)-2-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-5,7-dimethyl-oct-1-en-4-ol | 704882-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4R,5S,6S)-2-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-5,7-dimethyl-oct-1-en-4-ol
• 英文别名: (4R,5S,6S)-2-benzyl-6-[tert-butyl(dimethyl)silyl]oxy-5,7-dimethyloct-1-en-4-ol
• CAS: 704882-85-9
• 化学式: C₂₃H₄₀O₂Si
• 分子量: 376.655
• InChiKey: NCSGJCJDMYASCN-NNWRFLSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.22
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4R,5S,6S)-2-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-5,7-dimethyl-oct-1-en-4-ol 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 (3S,4S,5R)-7-Benzyl-2,4-dimethyl-oct-7-ene-3,5-diol
  参考文献：
  名称：

  Allyltrichlorostannane additions to chiral aldehydes

  摘要：

  Chiral and achiral allyltrichlorostannanes reacted with chiral beta-alkoxy and syn and anti alpha-methyl-beta-alkoxy aldehydes to give the corresponding homoallylic alcohols with moderate to high diastereoselectivities. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01713-1
• 作为产物：
  描述：

  (-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one 在 2,6-二甲基吡啶 、 锂硼氢 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (4R,5S,6S)-2-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-5,7-dimethyl-oct-1-en-4-ol
  参考文献：
  名称：

  Allyltrichlorostannane additions to chiral aldehydes

  摘要：

  Chiral and achiral allyltrichlorostannanes reacted with chiral beta-alkoxy and syn and anti alpha-methyl-beta-alkoxy aldehydes to give the corresponding homoallylic alcohols with moderate to high diastereoselectivities. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01713-1

文献信息

• Addition of lactate-derived chiral allyltrichlorostannanes to chiral aldehydes
  作者：Luiz C. Dias、Leonardo J. Steil

  DOI：10.1016/j.tetlet.2004.09.186

  日期：2004.11

  Chiral lactate-derived allyltrichlorostannanes reacted with chiral alpha-methyl beta-alkoxy and syn and anti alpha-methyl-beta-alkoxy aldehydes to give the corresponding homoallylic alcohols with moderate to high 1,4-syn-diastereoselectivities. (C) 2004 Elsevier Ltd. All rights reserved.
• Allyltrichlorostannane additions to chiral aldehydes
  作者：Luiz Carlos Dias、Débora Ribeiro dos Santos、Leonardo José Steil

  DOI：10.1016/s0040-4039(03)01713-1

  日期：2003.9

  Chiral and achiral allyltrichlorostannanes reacted with chiral beta-alkoxy and syn and anti alpha-methyl-beta-alkoxy aldehydes to give the corresponding homoallylic alcohols with moderate to high diastereoselectivities. (C) 2003 Elsevier Ltd. All rights reserved.