2-Amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid (4-chloro-phenyl)-amide | 394235-35-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid (4-chloro-phenyl)-amide
• 英文别名: 2-amino-N-(4-chlorophenyl)-5-cyano-1-[(4-methylphenyl)sulfonylamino]-4-methylsulfanyl-6-oxopyridine-3-carboxamide
• CAS: 394235-35-9
• 化学式: C₂₁H₁₈ClN₅O₄S₂
• 分子量: 503.99
• InChiKey: DKXRKPAPIWATPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  179
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-Amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid (4-chloro-phenyl)-amide 在 哌啶 、 一水合肼 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以75%的产率得到3,6-diamino-4-oxo-5-(toluene-4-sulfonylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridine-7-carboxylic acid (4-chloro-phenyl)-amide
  参考文献：
  名称：

  A NEW GENERAL METHOD FOR SUBSTITUTED 4-ALKYLTHIO-N-ARYLSULPHONYL-AMINO-2-PYRIDONES: REACTION OF KETENE-SS-ACETALS WITH ARYLSULPHONYLHYDRAZIDES

  摘要：

  A novel and efficient method for the synthesis of substituted 4-alkylthio-N-arylsulphonylamino-2-pyridones via the reaction of ketene-SS-acetals with N-cyanoacetoarylsulfonyl-hydrazides has been investigated. 1-Arylsulfonylamino-pyrazolo[3,4-c]pyridine-2(1H)-ones have also been prepared from the reaction of 4-alkylthio-N-arylsulfonylamino-2-pyridones with hydrazines.

  DOI：

  10.1080/10426500108040593
• 作为产物：
  描述：

  N'-(2-cyanoacetyl)-4-methylbenzenesulfonohydrazide 、 N-(4-chlorophenyl)-2-cyano-3,3-bis(methylthio)acrylamide 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以75%的产率得到2-Amino-5-cyano-4-methylsulfanyl-6-oxo-1-(toluene-4-sulfonylamino)-1,6-dihydro-pyridine-3-carboxylic acid (4-chloro-phenyl)-amide
  参考文献：
  名称：

  A NEW GENERAL METHOD FOR SUBSTITUTED 4-ALKYLTHIO-N-ARYLSULPHONYL-AMINO-2-PYRIDONES: REACTION OF KETENE-SS-ACETALS WITH ARYLSULPHONYLHYDRAZIDES

  摘要：

  A novel and efficient method for the synthesis of substituted 4-alkylthio-N-arylsulphonylamino-2-pyridones via the reaction of ketene-SS-acetals with N-cyanoacetoarylsulfonyl-hydrazides has been investigated. 1-Arylsulfonylamino-pyrazolo[3,4-c]pyridine-2(1H)-ones have also been prepared from the reaction of 4-alkylthio-N-arylsulfonylamino-2-pyridones with hydrazines.

  DOI：

  10.1080/10426500108040593

文献信息

• A NEW GENERAL METHOD FOR SUBSTITUTED 4-ALKYLTHIO-<i>N</i>-ARYLSULPHONYL-AMINO-2-PYRIDONES: REACTION OF KETENE-<i>SS</i>-ACETALS WITH ARYLSULPHONYLHYDRAZIDES
  作者：Galal H. Elgemeie、Hosny A. Ali、Ahmed H. Elghandour、Hassan M. Abdel-aziz

  DOI：10.1080/10426500108040593

  日期：2001.3.1

  A novel and efficient method for the synthesis of substituted 4-alkylthio-N-arylsulphonylamino-2-pyridones via the reaction of ketene-SS-acetals with N-cyanoacetoarylsulfonyl-hydrazides has been investigated. 1-Arylsulfonylamino-pyrazolo[3,4-c]pyridine-2(1H)-ones have also been prepared from the reaction of 4-alkylthio-N-arylsulfonylamino-2-pyridones with hydrazines.