methyl 3,5-bis(benzyloxy)-4-methylbenzoate | 34696-31-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3,5-bis(benzyloxy)-4-methylbenzoate
• 英文别名: Methyl 4-methyl-3,5-bis(phenylmethoxy)benzoate；methyl 4-methyl-3,5-bis(phenylmethoxy)benzoate
• CAS: 34696-31-6
• 化学式: C₂₃H₂₂O₄
• 分子量: 362.425
• InChiKey: BJZHHQKLNANLNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 3,5-bis(benzyloxy)-4-methylbenzoate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以94%的产率得到3,5-二羟基-4-甲基苯甲酸甲酯
  参考文献：
  名称：

  Preparation of Tricyclic Analog as CDE Ring Model of Renieramycin Marine Natural Product by Novel Photo-Induced Transformation of 6-Methoxy-1,2,3,4-Tetrahydroisoquinoline-5,8-dione

  摘要：

  DOI：

  10.3987/com-18-s(f)100
• 作为产物：
  描述：

  3,5-二羟基-4-甲基苯甲酸 在 potassium carbonate 、 对甲苯磺酸 作用下， 以 丙酮 为溶剂， 反应 33.0h， 生成 methyl 3,5-bis(benzyloxy)-4-methylbenzoate
  参考文献：
  名称：

  Preparation of Tricyclic Analog as CDE Ring Model of Renieramycin Marine Natural Product by Novel Photo-Induced Transformation of 6-Methoxy-1,2,3,4-Tetrahydroisoquinoline-5,8-dione

  摘要：

  DOI：

  10.3987/com-18-s(f)100

文献信息

• MULTIMERIC PROTECTED FLUORESCENT REAGENTS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20160237279A1

  公开（公告）日：2016-08-18

  Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.

  提供了多聚保护荧光试剂及其合成方法。这些试剂在各种基于荧光的分析方法中很有用，包括在高密度下分析高度多重光学反应，比如单分子实时核酸测序反应。这些试剂包含荧光染料元素，允许化合物在理想波长下以高灵敏度被检测，结合元素，允许化合物被目标生物分子特异性识别，以及保护屏障元素，减少荧光染料元素与结合的目标生物分子之间的不良接触，从而减少荧光染料元素对结合的目标生物分子的光损伤。这些试剂还包含耦合元素，将单体化合物连接成多聚形式，从而增加亮度。
• MODIFIED NUCLEOTIDE REAGENTS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20170321268A1

  公开（公告）日：2017-11-09

  Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.

  提供了包含至少一种亲和素蛋白、至少一种染料标记化合物和至少一种核苷酸化合物的标记核苷酸类似物。这些类似物在各种基于荧光的分析方法中很有用，包括在高密度下对大量高度多重光学反应进行分析，例如单分子实时核酸测序反应。这些类似物在理想波长下具有高灵敏度的可检测性。它们包含调节类似物与DNA聚合酶相互作用的结构组分，从而减少光损伤，并改善测序反应中类似物的动力学和其他性质。还提供了主题类似物的核苷酸和染料标记化合物，以及在制备这些化合物和类似物中有用的中间体。还提供了包含这些化合物的组合物、合成这些中间体、化合物和类似物的方法，以及突变的DNA聚合酶。
• The chemistry of fungi. Part LXI. The synthesis of (±)-sclerotiorin, of (±)-4,6-dimethylocta-trans-2,trans-4-dienoic acid, and of an analogue of rotiorin
  作者：R. Chong、R. R. King、W. B. Whalley

  DOI：10.1039/j39710003566

  日期：——

  Syntheses of (±)-sclerotiorin, the principal pigment of several fungi including Penicillium multicolor and P. sclerotiorum, of (±)-4,6-dimethylocta-trans-2,trans-4-dienoic acid [a major degradation product of (+)- and of (–)-sclerotiorin] and of (+)-5-chloroisorotiorin, an angular analogue of rotiorin, are described.

  （±）-sclerotiorin，几种真菌包括的主要颜料的合成多色青霉和P.菌核病，（±）-4,6- dimethylocta-的反式-2，反式-4-烯酸[主要的降解的产物（描述了（+）-和（-）-硬化蛋白]和（+）-5-氯异麦角蛋白（rotiorin的角类似物）。
• Protected dye-labeled reagents
  申请人：Pacific Biosciences of California, Inc.

  公开号：US10669299B2

  公开（公告）日：2020-06-02

  Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.

  提供了由至少一种阿维丁蛋白、至少一种染料标记化合物和至少一种核苷酸化合物组成的标记核苷酸类似物。这些类似物可用于各种基于荧光的分析方法，包括分析大量高密度的高度复用光学反应，如单分子实时核酸测序反应。类似物可在理想波长下以高灵敏度进行检测。它们含有结构成分，可调节类似物与 DNA 聚合酶的相互作用，从而减少光损伤，改善类似物在测序反应中的动力学和其他特性。此外，还提供了类似物的核苷酸和染料标记化合物，以及用于制备化合物和类似物的中间体。还提供了包含这些化合物的组合物，合成这些中间体、化合物和类似物的方法，以及突变 DNA 聚合酶。
• Modified nucleotide reagents
  申请人：Pacific Biosciences of California, Inc.

  公开号：US10676788B2

  公开（公告）日：2020-06-09

  Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.

  提供了由至少一种阿维丁蛋白、至少一种染料标记化合物和至少一种核苷酸化合物组成的标记核苷酸类似物。这些类似物可用于各种基于荧光的分析方法，包括分析大量高密度的高度复用光学反应，如单分子实时核酸测序反应。类似物可在理想波长下以高灵敏度进行检测。它们含有结构成分，可调节类似物与 DNA 聚合酶的相互作用，从而减少光损伤，改善类似物在测序反应中的动力学和其他特性。此外，还提供了类似物的核苷酸和染料标记化合物，以及用于制备化合物和类似物的中间体。还提供了包含这些化合物的组合物，合成这些中间体、化合物和类似物的方法，以及突变 DNA 聚合酶。