2-(Cyclohexylamino)-4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(Cyclohexylamino)-4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]benzamide
• 英文别名: 2-(cyclohexylamino)-4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]benzamide
• 化学式: C₂₃H₂₇F₃N₄O₂
• 分子量: 448.5
• InChiKey: UPCZWVHVQUQZJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  90
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• METHOD FOR TREATING CANCER USING HSP90 INHIBITORS
  申请人：Al Therapeutics, Inc.

  公开号：US20210030759A1

  公开（公告）日：2021-02-04

  The disclosure also provides compositions and methods related to combination therapy with HSP90 inhibitors and BCL-2 pathway inhibitors for treating cancer. The disclosure also provides compositions and methods related to the use of ‘low dose’ HSP90 inhibitors in the treatment of cancer, alone and in combination with other therapeutic agents.
• CONJUGATES FOR DELIVERING AN ANTI-CANCER AGENT TO NERVE CELLS, METHODS OF USE AND METHODS OF MAKING THEREOF
  申请人：Manzanita Pharmaceuticals, Inc.

  公开号：US20210147499A1

  公开（公告）日：2021-05-20

  Conjugates for delivering an anti-cancer agent to nerve cells are provided. Conjugate compounds of the present disclosure according to certain embodiments include a compound having a protein, peptide or pepetidomimetic that binds selectively to a neurotrophin receptor, an anti-cancer agent and a linker that covalently bonds the anti-cancer agent to the protein, peptide or pepetidomimetic binds selectively to the neurotrophin receptor. Compositions and methods for delivering an anti-cancer agent selectively into nerve cells (e.g., in the treatment of optic pathway glioma) as well as indications such as perineural invasion and skin cancers are also described. Also provided are methods of making the anti-cancer conjugate compounds.
• [EN] COMBINATION THERAPIES USING INDAZOLYLBENZAMIDE DERIVATIVES FOR THE TREATMENT OF CANCER<br/>[FR] POLYTHÉRAPIES UTILISANT DES DÉRIVÉS D'INDAZOLYLBENZAMIDE POUR LE TRAITEMENT DU CANCER
  申请人：ESANEX INC

  公开号：WO2017201226A1

  公开（公告）日：2017-11-23

  The invention relates to combination therapies useful in the treatment and/or prevention of cancer.
• [EN] METHODS OF TREATING CORONAVIRUS INFECTION USING HSP90 INHIBITORS<br/>[FR] PROCÉDÉS DE TRAITEMENT D'UNE INFECTION À CORONAVIRUS AU MOYEN D'INHIBITEURS DE HSP90
  申请人：UNIV DUKE

  公开号：WO2021263139A1

  公开（公告）日：2021-12-30

  This present disclosure is directed to methods of use related to heat shock protein 90 inhibitors (HSP90i) to treat, prevent and/or reduce the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, or treating or inhibiting coronavirus disease (COVID-19) in a subject.