(γ-dimethylamino)propylamino-1 methyl-4 hydroxy-8-5H-pyrido <4,3-b> indole | 111380-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (γ-dimethylamino)propylamino-1 methyl-4 hydroxy-8-5H-pyrido <4,3-b> indole
• 英文别名: 1-(3-dimethylamino propylamino)-8-hydroxy-4-methyl-5H-pyrido[4,3-b]indole；5H-Pyrido(4,3-b)indol-8-ol, 1-((3-(dimethylamino)propyl)amino)-4-methyl-；1-[3-(dimethylamino)propylamino]-4-methyl-5H-pyrido[4,3-b]indol-8-ol
• CAS: 111380-24-6
• 化学式: C₁₇H₂₂N₄O
• 分子量: 298.388
• InChiKey: QYXMBJGTKLOZRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  64.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl-4 benzoyloxy-8-2H,5H-pyrido <4,3-b> indole-one-1 在 三氯氧磷 作用下， 反应 406.0h， 生成 (γ-dimethylamino)propylamino-1 methyl-4 hydroxy-8-5H-pyrido <4,3-b> indole
  参考文献：
  名称：

  玫瑰树碱合成类似物：4,5h-吡啶甲基[4,3-b]吲哚（γ-咔啉）甲基变体亚砜类混合物1,5等。

  摘要：

  已经找到了几种将1-官能化的4-甲基-5H-吡啶基[4,3-b]吲哚方法：

  DOI：

  10.1016/s0040-4020(01)89985-3

文献信息

• 1-Amino-substituted 4-methyl-5H-pyrido[4,3-b]indoles (.gamma.-carbolines) as tricyclic analogs of ellipticines: a new class of antineoplastic agents
  作者：Emile Bisagni、Nguyen Chi Hung、Alain Pierre、Odile Pepin、Paul De Cointet、Pierre Gros

  DOI：10.1021/jm00397a023

  日期：1988.2

  A series of 1-amino-substituted 4-methyl-5H-pyrido[4,3-b]indoles that are structurally related to ellipticines by deletion of a ring have been synthesized in order to evaluate their DNA affinity, their in vitro cytotoxicity on L1210 cultured cells, and their in vivo antitumor activity. Among 24 derivatives that have been prepared and studied for the structure-activity relationship in this new class of antineoplastic agents, those that have a NH(CH2)3N(R)2 side chain (R = CH3 or C2H5) at their 1-position, a 4-methyl group, and an 8-OH substituent, either with a 5-NH or with a 5-NCH3 group, show the most potent cytotoxicities on L1210 cultured cells and in vivo antitumor properties in P388 and L1210 leukemia systems. In vivo antineoplastic activity of the most potent products was confirmed in P388 and L1210 leukemia systems. In vivo antineoplastic activity of the most potent products was confirmed on other mouse experimental tumors from the standard NCI screening:B16 melanoma and C38 adenocarcinoma.
• BISAGNI, EMILE;NGUYEN, CHI HUNG;PIERRE, ALAIN;PEPIN, ODILE;COINTET, PAUL +, J. MED. CHEM., 31,(1988) N 2, 398-405
  作者：BISAGNI, EMILE、NGUYEN, CHI HUNG、PIERRE, ALAIN、PEPIN, ODILE、COINTET, PAUL +

  DOI：——

  日期：——
• Dérivés du pyridoindole, leur application à titre de médicaments et les compositions les renfermant
  申请人：SANOFI

  公开号：EP0239476B1

  公开（公告）日：1990-10-24
• US4835160A
  申请人：——

  公开号：US4835160A

  公开（公告）日：1989-05-30