ethyl 5-(bromomethyl)-1H-pyrazole-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 5-(bromomethyl)-1H-pyrazole-4-carboxylate
• 化学式: C₇H₉BrN₂O₂
• 分子量: 233.06
• InChiKey: VWTNZKYDSYVXQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] INHIBITORS OF CBL-B AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE CBL-B ET LEURS PROCÉDÉS D'UTILISATION
  申请人：NURIX THERAPEUTICS INC

  公开号：WO2019148005A1

  公开（公告）日：2019-08-01

  Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo.

  揭示了用于抑制泛素蛋白酶体途径中的E3酶Cbl-b的化合物、组合物和使用方法。这些化合物、组合物和方法可用于调节免疫系统，治疗适合免疫系统调节的疾病，并用于体内、体外或体外细胞的治疗。
• INHIBITORS OF CBL-B AND METHODS OF USE THEREOF
  申请人：Nurix Therapeutics, Inc.

  公开号：EP3743063A1

  公开（公告）日：2020-12-02
• AMINO-ACID ANILIDES AS SMALL MOLECULE MODULATORS OF IL-17
  申请人：Leo Pharma A/S

  公开号：EP3897623A1

  公开（公告）日：2021-10-27
• [EN] AMINO-ACID ANILIDES AS SMALL MOLECULE MODULATORS OF IL-17<br/>[FR] ANILIDES D'ACIDES AMINÉS EN TANT QUE MODULATEURS À PETITES MOLÉCULES D'IL-17
  申请人：LEO PHARMA AS

  公开号：WO2020127685A1

  公开（公告）日：2020-06-25

  The present invention relates to a compound according to formula I (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.