2-(4-chlorophenyl)-7-methylimidazo[2,1-b]benzothiazole | 7025-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-chlorophenyl)-7-methylimidazo[2,1-b]benzothiazole
• 英文别名: 2-<4-Chlor-phenyl>-7-methyl-imidazo<2,1-b>benzthiazol；2-(4-chloro-phenyl)-7-methyl-benzo[d]imidazo[2,1-b]thiazole；2-(4-chlorophenyl)-6-methylimidazo[2,1-b][1,3]benzothiazole
• CAS: 7025-34-5
• 化学式: C₁₆H₁₁ClN₂S
• 分子量: 298.796
• InChiKey: NLEQCCUTMXYPNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯苯乙酮 以 乙醇 、 乙腈 为溶剂， 反应 2.0h， 生成 2-(4-chlorophenyl)-7-methylimidazo[2,1-b]benzothiazole
  参考文献：
  名称：

  A convenient [hydroxy(tosyloxy)iodo]benzene-mediated one-pot synthesis of 2-arylimidazo[2,1-b]benzothiazoles

  摘要：

  Several 2-arylimidazo[2,1-b]benzothiazoles (4) have been conveniently synthesized in one-pot reactions via alpha-tosyloxylation of enolizable ketones (1) using [hydroxy(tosyloxy)iodo]benzene 2 in acetonitrile, followed by treatment with 2-amino-6-(substituted)benzothiazoles (3). The present protocol offers several advantages towards general access of 2-arylimidazo[2,1-b]benzothiazoles, including an intriguing alternative to the literature protocols, a readily available nontoxic reagent, operational simplicity and an environmentally benign procedure.

  DOI：

  10.1080/17415993.2014.996221

文献信息

• Buu-Hoi,N.P. et al., Bulletin de la Societe Chimique de France, 1966, p. 1277 - 1279
  作者：Buu-Hoi,N.P. et al.

  DOI：——

  日期：——
• Patra,M. et al., Journal of the Indian Chemical Society, 1974, vol. 51, p. 1031 - 1034
  作者：Patra,M. et al.

  DOI：——

  日期：——
• A convenient [hydroxy(tosyloxy)iodo]benzene-mediated one-pot synthesis of 2-arylimidazo[2,1-<i>b</i>]benzothiazoles
  作者：Garima Sumran、Ranjana Aggarwal

  DOI：10.1080/17415993.2014.996221

  日期：2015.3.4

  Several 2-arylimidazo[2,1-b]benzothiazoles (4) have been conveniently synthesized in one-pot reactions via alpha-tosyloxylation of enolizable ketones (1) using [hydroxy(tosyloxy)iodo]benzene 2 in acetonitrile, followed by treatment with 2-amino-6-(substituted)benzothiazoles (3). The present protocol offers several advantages towards general access of 2-arylimidazo[2,1-b]benzothiazoles, including an intriguing alternative to the literature protocols, a readily available nontoxic reagent, operational simplicity and an environmentally benign procedure.