[4-(2-Azidoethyl)-1,3-oxazol-2-yl]methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [4-(2-Azidoethyl)-1,3-oxazol-2-yl]methanol
• 英文别名: [4-(2-azidoethyl)-1,3-oxazol-2-yl]methanol
• 化学式: C6H8N4O2
• 分子量: 168.15
• InChiKey: MEHPAQWLROSMRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP1263718A1

  公开（公告）日：2002-12-11
• [EN] NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES<br/>[FR] NOUVELLE UTILISATION DE DERIVES DE PHENYLHETEROALKYLAMINE
  申请人：ASTRAZENECA AB

  公开号：WO2001062721A1

  公开（公告）日：2001-08-30

  There is disclosed the use of a compound of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prohylaxis of inflammatory disease.