1-Piperidin-1-yl-2-(3,4,5-trimethoxy-phenyl)-ethanone | 121557-71-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Piperidin-1-yl-2-(3,4,5-trimethoxy-phenyl)-ethanone
• 英文别名: 1-Piperidin-1-yl-2-(3,4,5-trimethoxyphenyl)ethanone
• CAS: 121557-71-9
• 化学式: C₁₆H₂₃NO₄
• 分子量: 293.363
• InChiKey: ZILNYYJMMRVKQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Piperidin-1-yl-2-(3,4,5-trimethoxy-phenyl)-ethanone 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以80%的产率得到N-<2-(3,4,5-Trimethoxyphenyl)-1-thioxoethyl>piperidine
  参考文献：
  名称：

  Lee, Ving J.; Curran, William V.; Fields, Thomas F., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1873 - 1891

  摘要：

  DOI：

文献信息

• LEE, VING J.;CURRAN, WILLIAM V.;FIELDS, THOMAS F.;LEARN, KEITH, J. HETEROCYCL. CHEM., 25,(1988) N, C. 1873-1891
  作者：LEE, VING J.、CURRAN, WILLIAM V.、FIELDS, THOMAS F.、LEARN, KEITH

  DOI：——

  日期：——
• TUNABLE ENDOGENOUS PROTEIN DEGRADATION
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20180179522A1

  公开（公告）日：2018-06-28

  The present invention provides a means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knock-out or knock-in strategies and strategies that provide for correction, or alteration, of single nucleotides. The invention includes inserting into the genome a nucleotide encoding a heterobifunctional compound targeting protein (dTAG) in-frame with the nucleotide sequence of a gene encoding an endogenously expressed protein of interest which, upon expression, produces an endogenous protein-dTAG hybrid protein. This allows for targeted protein degradation of the dTAG and the fused endogenous protein using a heterobifunctional compound.
• Lee, Ving J.; Curran, William V.; Fields, Thomas F., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1873 - 1891
  作者：Lee, Ving J.、Curran, William V.、Fields, Thomas F.、Learn, Keith

  DOI：——

  日期：——