(E)-3-(2,4-dimethoxyphenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-3-(2,4-dimethoxyphenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one
• 化学式: C₂₀H₂₂O₇
• 分子量: 374.4
• InChiKey: UTJMJQDLFFHCNE-VQHVLOKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Small molecule modulators of microRNA-34a
  申请人：The Chinese University of Hong Kong

  公开号：US10865176B2

  公开（公告）日：2020-12-15

  The present invention provides methods for identifying compounds that act as miR-34a modulators. The present invention also provides miR-34a modulators and compositions containing the modulators. The present invention further provides methods for treating diseases by administration of miR-34a modulators.

  本发明提供了鉴定作为 miR-34a 调节剂的化合物的方法。本发明还提供了 miR-34a 调节剂和含有该调节剂的组合物。本发明进一步提供了通过施用 miR-34a 调节剂治疗疾病的方法。
• Catechin and gingerol loaded nanomedicine
  申请人：King Abdulaziz University

  公开号：US11129797B1

  公开（公告）日：2021-09-28

  A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.

  一种用于治疗肥胖症的纳米药物，该药物包含贵金属纳米颗粒，其表面配体包含(+)-儿茶素（2R,3S）和姜酚的混合物，或者包含吸附了(+)-儿茶素（2R,3S）和姜酚混合物的碳纳米材料颗粒。此外，还提供了一种制造贵金属纳米药物和碳纳米药物的方法。该纳米药物可用于治疗肥胖症。
• Method for making a noble metal nanomedicine
  申请人：King Abdulaziz University

  公开号：US11234940B1

  公开（公告）日：2022-02-01

  A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.

  一种用于治疗肥胖症的纳米药物，该药物包含贵金属纳米颗粒，其表面配体包含(+)-儿茶素（2R,3S）和姜酚的混合物，或者包含吸附了(+)-儿茶素（2R,3S）和姜酚混合物的碳纳米材料颗粒。此外，还提供了一种制造贵金属纳米药物和碳纳米药物的方法。该纳米药物可用于治疗肥胖症。
• Metal nanoparticle medicine with a mixture of natural ligands
  申请人：King Abdulaziz University

  公开号：US11219605B1

  公开（公告）日：2022-01-11

  A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.

  一种用于治疗肥胖症的纳米药物，该药物包含贵金属纳米颗粒，其表面配体包含(+)-儿茶素（2R,3S）和姜酚的混合物，或者包含吸附了(+)-儿茶素（2R,3S）和姜酚混合物的碳纳米材料颗粒。此外，还提供了一种制造贵金属纳米药物和碳纳米药物的方法。该纳米药物可用于治疗肥胖症。
• Carbon nanomedicine with natural ligands
  申请人：King Abdulaziz University

  公开号：US11311492B1

  公开（公告）日：2022-04-26

  A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.

  本发明涉及一种用于治疗肥胖症的纳米药物，其成分包括：要么包含具有表面配体的贵金属纳米粒子，所述表面配体由混合物组成，所述混合物包括(+)-儿茶素(2R,3S)和姜酚；要么包含碳纳米材料颗粒，所述颗粒吸附有由混合物组成的混合物，所述混合物包括(+)-儿茶素(2R,3S)和姜酚。本发明还提供了一种制备所述贵金属纳米药物和碳纳米药物的方法。该纳米药物用于治疗肥胖症的方法。