(5S,6R,15S)-5,6,15-Trihydroxy-7,9,11,13,17-icosapentaensaeure | 110657-98-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5S,6R,15S)-5,6,15-Trihydroxy-7,9,11,13,17-icosapentaensaeure
• 英文别名: (5S,6R,7E,9E,11Z,13E,15S,17Z)-5,6,15-trihydroxyicosa-7,9,11,13,17-pentaenoic acid
• CAS: 110657-98-2
• 化学式: C₂₀H₃₀O₅
• 分子量: 350.455
• InChiKey: ZZMKOZNTEJVKRY-YJUORNCYSA-N

物化性质

• 沸点：
  591.3±50.0 °C(Predicted)
• 密度：
  1.112±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：50 mg/ml；乙醇：50 mg/ml； PBS（pH 7.2）：1 mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (Z)-(S)-2-(tert-Butyl-dimethyl-silanyloxy)-hept-4-enal 在 Lindlar's catalyst 喹啉 、 chromium dichloride 、 正丙胺 、 lithium hydroxide 、 copper(l) iodide 、 四(三苯基膦)钯 、 氢气 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 苯 为溶剂， 反应 8.0h， 生成 (5S,6R,15S)-5,6,15-Trihydroxy-7,9,11,13,17-icosapentaensaeure
  参考文献：
  名称：

  Nicolaou, K. C.; Webber, S. E.; Ramphal, J., Angewandte Chemie, 1987, vol. 99, # 10, p. 1077 - 1079

  摘要：

  DOI：

文献信息

• Oils with anti-inflammatory activity containing natural specialized proresolving mediators and their precursors
  申请人：SOLUTEX NA LLC

  公开号：US10568858B2

  公开（公告）日：2020-02-25

  The present invention encompasses oils that have anti-inflammatory or resolution-stimulating activity that contain or are enriched with Specialized Proresolving Mediators (SPM) or SPM precursors, which originate from an oil obtained from organisms containing long chain omega-3 polyunsaturated fatty acids, such as fish, crustaceae, algae, and mollusks. The invention also encompasses a method for the production of these oils, and the utilization of the oils for nutritional supplements, pharmaceutical formulations, and cosmetic formulations, which can be employed for treating an inflammatory condition.

  本发明包括具有抗炎或刺激溶解活性的油类，这些油类含有或富含特化促溶解介质（SPM）或 SPM 前体，这些特化促溶解介质或 SPM 前体来源于从含有长链欧米加-3 多不饱和脂肪酸的生物（如鱼类、甲壳类、藻类和软体动物）中获得的油类。本发明还包括生产这些油的方法，以及将这些油用于营养补充剂、药物制剂和化妆品制剂的方法，这些制剂可用于治疗炎症。
• Oils with anti-inflammatory activity containing natural Specialized Proresolving Mediators and their precursors
  申请人：Solutex NA LLC

  公开号：US11077083B2

  公开（公告）日：2021-08-03

  The present invention encompasses oils that have anti-inflammatory or resolution-stimulating activity that contain or are enriched with Specialized Proresolving Mediators (SPM) or SPM precursors, which originate from an oil obtained from organisms containing long chain omega-3 polyunsaturated fatty acids, such as fish, crustaceae, algae, and mollusks. The invention also encompasses a method for the production of these oils, and the utilization of the oils for nutritional supplements, pharmaceutical formulations, and cosmetic formulations, which can be employed for treating an inflammatory condition.

  本发明包括具有抗炎或刺激溶解活性的油类，这些油类含有或富含特化促溶解介质（SPM）或 SPM 前体，这些特化促溶解介质或 SPM 前体来源于从含有长链欧米加-3 多不饱和脂肪酸的生物（如鱼类、甲壳类、藻类和软体动物）中获得的油类。本发明还包括生产这些油的方法，以及将这些油用于营养补充剂、药物制剂和化妆品制剂的方法，这些制剂可用于治疗炎症。
• Treatment of vulvar pain
  申请人：University of Rochester

  公开号：US11400057B2

  公开（公告）日：2022-08-02

  The present invention relates to methods of treating female reproductive tract irritation (such as pain and pruritus) or/and inflammation.

  本发明涉及治疗女性生殖道刺激（如疼痛和瘙痒）或/和炎症的方法。
• NICOLAOU, K. C.;WEBBER, S. E.;RAMPHAL, J.;ABE, Y., ANGEW. CHEM., 99,(1987) N 10, 1077-1079
  作者：NICOLAOU, K. C.、WEBBER, S. E.、RAMPHAL, J.、ABE, Y.

  DOI：——

  日期：——
• OILS WITH ANTI-INFLAMMATORY ACTIVITY CONTAINING NATURAL SPECIALIZED PRORESOLVING MEDIATORS AND THEIR PRECURSORS
  申请人：SOLUTEX NA LLC

  公开号：US20150126602A1

  公开（公告）日：2015-05-07

  The present invention encompasses oils that have anti-inflammatory or resolution-stimulating activity that contain or are enriched with Specialized Proresolving Mediators (SPM) or SPM precursors, which originate from an oil obtained from organisms containing long chain omega-3 polyunsaturated fatty acids, such as fish, crustaceae, algae, and mollusks. The invention also encompasses a method for the production of these oils, and the utilization of the oils for nutritional supplements, pharmaceutical formulations, and cosmetic formulations, which can be employed for treating an inflammatory condition.