N-(2-(3-(2-aminoethoxy)propoxy)ethyl)-4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(2-(3-(2-aminoethoxy)propoxy)ethyl)-4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzamide
• 英文别名: N-[2-[3-(2-aminoethoxy)propoxy]ethyl]-4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)imidazol-1-yl]methyl]benzamide
• 化学式: C₄₀H₄₀F₆N₄O₅
• 分子量: 770.772
• InChiKey: ZCAVVPQMDLKPCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  55
• 可旋转键数：
  17
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• NOVEL IMIDAZOLE DERIVATIVE AND THERAPEUTICAL USE THEREOF
  申请人：Industry-Academic Cooperation Foundation, Yonsei University

  公开号：EP3050875B1

  公开（公告）日：2019-03-13
• NOVEL IMIDAZOLE DERIVATIVES AND THERAPEUTIC USE THEREOF
  申请人：INDUSTRY-ACA-DEMIC COORPERATION FOUNDATION, YONSEI UNIVERSITY

  公开号：US20160297768A1

  公开（公告）日：2016-10-13

  The present invention relates to a novel imidazole derivative, a pharmaceutical acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The imidazole derivative of the present invention has excellent apoptosis activity, and thus can be useful for treating various hyperproliferative diseases including cancer.
• [EN] NOVEL IMIDAZOLE DERIVATIVE AND THERAPEUTICAL USE THEREOF<br/>[FR] NOUVEAU DÉRIVÉ D'IMIDAZOLE ET UTILISATION THÉRAPEUTIQUE DE CE DERNIER<br/>[KO] 신규한 이미다졸 유도체 및 이의 치료학적 용도
  申请人：UNIV YONSEI IACF

  公开号：WO2015046647A1

  公开（公告）日：2015-04-02

  본 발명은 신규한 이미다졸 유도체 또는 이의 약제학적으로 허용 가능한 염 및 이들을 유효성분으로 포함하는 암의 예방 또는 치료용 약제학적 조성물에 관한 것이다. 본 발명의 이미다졸 유도체는 우수한 세포사멸 활성을 가져, 암을 비롯한 다양한 과대증식성 질환의 치료에 유용하게 이용될 수 있다.