1-Aminocarbonylmethyl-3,4-dihydro-isochinolin | 19622-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 英文名称: 1-Aminocarbonylmethyl-3,4-dihydro-isochinolin
• 英文别名: 3,4-Dihydro-1-isoquinolineacetamide；2-(3,4-dihydroisoquinolin-1-yl)acetamide
• CAS: 19622-86-7
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.229
• InChiKey: HFAWQWOCJFNGDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pyrazole derivative
  申请人：——

  公开号：US20010011090A1

  公开（公告）日：2001-08-02

  Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-dependent calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-dependent calcium channel inhibitors containing the above compounds as the active ingredient, 1 (in the formula, each symbol has the following meaning: B: phenylene, a nitrogen-containing, divalent, saturated ring group, or a monocyclic, divalent heteroaromatic ring group which may be substituted with Alk, X: —NR 1 —CR 2 R 3 —, —CR 2 R 3 —NR 1 —, —NR 1 SO 2 —, —SO 2 —NR 1 — or —CR 4 ═CR 5 —, and A: benzene ring which may have one or more substituents; mono-, di- or tricyclic fused heteroaryl which may have one or more substituents; cycloalkyl which may have one or more substituents; a nitrogen-containing, saturated ring group which may have one or more substituents; lower alkenyl which may have one or more substituents; lower alkynyl which may have one or more substituents; or Alk which may have one or more substituents).

  药物，特别是由以下一般公式（I）代表的吡唑衍生物，具有依赖钙释放的钙通道抑制作用和药用组合物，特别是含有上述化合物作为活性成分的依赖钙释放的钙通道抑制剂，1（在公式中，每个符号具有以下含义：B：苯基，含氮，二价，饱和环基，或带有Alk取代基的单环，二价杂芳环基；X：—NR1—CR2R3—，—CR2R3—NR1—，—NR1SO2—，—SO2—NR1—或—CR4═CR5—，和A：苯环，可能具有一个或多个取代基；单环、双环或三环融合的杂芳基，可能具有一个或多个取代基；可能具有一个或多个取代基的环烷基；可能具有一个或多个取代基的含氮饱和环基；可能具有一个或多个取代基的低烯基；可能具有一个或多个取代基的低炔基；或可能具有一个或多个取代基的Alk）。
• PYRAZOLE DERIVATIVES
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1024138A1

  公开（公告）日：2000-08-02

  Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-dependent calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-dependent calcium channel inhibitors containing the above compounds as the active ingredient, (in the formula, each symbol has the following meaning: D: pyrazolyl which may have 1 to 3 substituents selected from the group consisting of -Alk, -lower alkenyl, -lower alkynyl, -halogeno-lower alkyl, -Alk-cycloalkyl, -Alk-O-Alk, -cycloalkyl, -O-Alk, -COOH, -COO-Alk and -Hal, n: 0 or 1, B: phenylene, a nitrogen-containing, divalent, saturated ring group, or a monocyclic, divalent heteroaromatic ring group which may be substituted with Alk, X: -NR1-CR2R3-, -CR2R3-NR1-, -NR1-SO2-, -SO2-NR1- or -CR4=CR5-, and A: benzene ring which may have one or more substituents; mono-, di- or tricyclic fused heteroaryl which may have one or more substituents; cycloalkyl which may have one or more substituents; a nitrogen-containing, saturated ring group which may have one or more substituents; lower alkenyl which may have one or more substituents; lower alkynyl which may have one or more substituents; or Alk which may have one or more substituents).

  具有钙释放依赖性钙通道抑制作用的药物，特别是由以下通式(I)代表的吡唑衍生物，以及药物组合物，特别是含有上述化合物作为活性成分的钙释放依赖性钙通道抑制剂、 (式中各符号含义如下： D：吡唑基，可具有 1 至 3 个取代基，这些取代基选自由-Alk、-低级烯基、-低级炔基、-卤代低级烷基、-Alk-环烷基、-Alk-O-Alk、-环烷基、-O-Alk、-COOH、-COO-Alk 和-Hal 组成的组、 n:0或1、 B：亚苯基、含氮二价饱和环基或可被 Alk 取代的单环二价杂芳香环基、 X：-NR1-CR2R3-、-CR2R3-NR1-、-NR1-SO2-、-SO2-NR1-或-CR4=CR5-，以及 A：可具有一个或多个取代基的苯环；可具有一个或多个取代基的单环、二环或三环融合杂芳基；可具有一个或多个取代基的环烷基；可具有一个或多个取代基的含氮饱和环基；可具有一个或多个取代基的低级烯基；可具有一个或多个取代基的低级炔基；或可具有一个或多个取代基的烷基）。
• US6348480B1
  申请人：——

  公开号：US6348480B1

  公开（公告）日：2002-02-19
• US6958339B2
  申请人：——

  公开号：US6958339B2

  公开（公告）日：2005-10-25
• US7285554B2
  申请人：——

  公开号：US7285554B2

  公开（公告）日：2007-10-23