1-[4-[(E)-3-[4-[bis(2-hydroxyethyl)amino]phenyl]prop-2-enoyl]phenyl]-3-[(4-methoxyphenyl)methyl]urea

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-[4-[(E)-3-[4-[bis(2-hydroxyethyl)amino]phenyl]prop-2-enoyl]phenyl]-3-[(4-methoxyphenyl)methyl]urea
• 化学式: C₂₈H₃₁N₃O₅
• 分子量: 489.6
• InChiKey: NONNROWHOGKMKT-GIDUJCDVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  111
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] CHALCONE-UREA DERIVATIVES AS INSULIN SENSORS<br/>[FR] DÉRIVÉS DE CHALCONE-URÉE UTILISÉS EN TANT QUE CAPTEURS D'INSULINE
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2015080665A1

  公开（公告）日：2015-06-04

  The invention relates to compounds of formula (I) or derivatives, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites or prodrugs thereof, in which the substituents are as defined in the specification. These compounds may be useful as insulin sensors; in insulin secretion studies and as probes for insulin detection.

  本发明涉及式(I)化合物或其衍生物、互变异构体、立体异构体、多晶型、水合物、溶剂物、药学上可接受的盐、药物组合物、代谢物或其前药物。其中，取代基在说明书中定义。这些化合物可以用作胰岛素传感器，用于胰岛素分泌研究和作为胰岛素检测的探针。
• CHALCONE-UREA DERIVATIVES AS INSULIN SENSORS
  申请人：Agency for Science, Technology and Research

  公开号：US20170168073A1

  公开（公告）日：2017-06-15

  The invention relates to compounds of formula (I) or derivatives, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites or prodrugs thereof, in which the substituents are as defined in the specification. These compounds may be useful as insulin sensors; in insulin secretion studies and as probes for insulin detection.