2-(4-bromophenyl)-1H-imidazo[4,5-b]phenazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(4-bromophenyl)-1H-imidazo[4,5-b]phenazine
• 化学式: C₁₉H₁₁BrN₄
• 分子量: 375.227
• InChiKey: BLHYLCJYPQUFBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.09
• 重原子数：
  24.0
• 可旋转键数：
  1.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.46
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-(4-bromophenyl)-1H-imidazo[4,5-b]phenazine 、 四丁基氟化铵 以 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  A highly efficient and selective probe for F− detection based on 1H-imidazo[4,5-b]phenazine derivative

  摘要：

  A new colorimetric and fluorimetric chemosensor for F- detection based on 1H-imidazo[4,5b]phenazine derivative has been designed and synthesized. It shows excellent fluorescent specific selectivity and sensitivity for F- in DMSO solution. Upon addition of F- to the solution of probe 1, a remarkable color change from yellow to red could be observed easily by the naked-eye. The detection limit of this probe toward F- is 6.2 x 10(-6) mol/L. Analysis by H-1 NMR proved that the imidazolyl N-H could be hydrogen-bonded with added fluoride anions, and results in the difference of colors. (C) 2014 Rui Liu and Hong-Jun Zhu. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved.

  DOI：

  10.1016/j.cclet.2014.10.028
• 作为产物：
  描述：

  2,3-二氨基吩嗪 、 对溴苯甲醛 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以78%的产率得到2-(4-bromophenyl)-1H-imidazo[4,5-b]phenazine
  参考文献：
  名称：

  A highly efficient and selective probe for F− detection based on 1H-imidazo[4,5-b]phenazine derivative

  摘要：

  A new colorimetric and fluorimetric chemosensor for F- detection based on 1H-imidazo[4,5b]phenazine derivative has been designed and synthesized. It shows excellent fluorescent specific selectivity and sensitivity for F- in DMSO solution. Upon addition of F- to the solution of probe 1, a remarkable color change from yellow to red could be observed easily by the naked-eye. The detection limit of this probe toward F- is 6.2 x 10(-6) mol/L. Analysis by H-1 NMR proved that the imidazolyl N-H could be hydrogen-bonded with added fluoride anions, and results in the difference of colors. (C) 2014 Rui Liu and Hong-Jun Zhu. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved.

  DOI：

  10.1016/j.cclet.2014.10.028

文献信息

• SLUKA, J.;ZIKAN, V.;DANEK, J., CS. FARM, 37,(1988) N 2, 65-70
  作者：SLUKA, J.、ZIKAN, V.、DANEK, J.

  DOI：——

  日期：——