4'-Hydroxy-4-methoxy-2'-methylchalcone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4'-Hydroxy-4-methoxy-2'-methylchalcone
• 英文别名: (E)-1-(4-hydroxy-2-methylphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
• 化学式: C₁₇H₁₆O₃
• 分子量: 268.31
• InChiKey: AJFTWGKYXHISKT-BJMVGYQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• USE OF CHALCONES FOR THE TREATMENT OF VIRAL DISORDERS
  申请人：Johnson and Johnson Consumer Companies, Inc.

  公开号：EP1888174A1

  公开（公告）日：2008-02-20
• Use of chalcones for the treatment of viral disorders
  申请人：Boddupalli Sekhar

  公开号：US20060270614A1

  公开（公告）日：2006-11-30

  The present invention relates to chalcone derivatives and compositions containing such derivatives useful in the treatment of viral disorders, including but not limited to the treatment of viral lesions resulting from viruses such as Herpes Simplex virus.
• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.
• ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：US20190008797A1

  公开（公告）日：2019-01-10

  Provided herein is a coligand for the estrogen receptor (ER) a subunit, and methods of use thereof in treating conditions associated with ER signaling in an individual. The present ERα coligand may be a cell type-selective, allosteric modulator of ERα signaling. The ERα coligand, when administered to an individual, may modulate ER agonist-dependent signaling in a tissue-selective manner.
• [EN] USE OF CHALCONES FOR THE TREATMENT OF VIRAL DISORDERS<br/>[FR] UTILISATION DE CHALCONES POUR TRAITER DES TROUBLES D'ORDRE VIRAL
  申请人：JOHNSON & JOHNSON CONSUMER

  公开号：WO2006127539A1

  公开（公告）日：2006-11-30

  [EN] The present invention relates to chalcone derivatives and compositions containin such derivatives useful in the treatment of viral disorders, including but not limited to the treatment of viral lesions resulting from viruses such as Herpes Simplex virus.
  [FR] L'invention concerne des dérivés de chalcone et des compositions contenant ces dérivés, qui sont utiles pour traiter des troubles d'ordre viral, y compris mais pas exclusivement pour traiter des lésions virales dues à des virus tels que l'Herpes Simplex.