1-(2-ethyl-phenyl)-1H-imidazole | 25364-41-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-ethyl-phenyl)-1H-imidazole
• 英文别名: 1H-Imidazole, 1-(2-ethylphenyl)-；1-(2-ethylphenyl)imidazole
• CAS: 25364-41-4
• 化学式: C₁₁H₁₂N₂
• 分子量: 172.23
• InChiKey: MQZSSWAZHBYHAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] METHODS OF TREATING OR PREVENTING PSORIASIS, AND/OR ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES<br/>[FR] PROCÉDÉ DE TRAITEMENT PRÉVENTIF OU CURATIF DU PSORIASIS ET/OU DE LA MALADIE D'ALZHEIMER AU MOYEN DE DÉRIVÉS INDANE D'ACIDE ACÉTIQUE
  申请人：DARA BIOSCIENCES INC

  公开号：WO2010141696A1

  公开（公告）日：2010-12-09

  The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing psoriasis and/or Alzheimer's diseases.

  本发明提供了茚乙酸及其衍生物，以及用于治疗和/或预防牛皮癣和/或阿尔茨海默病的方法。
• [EN] 3H-IMIDAZO[4,5-b]PYRIDIN-5-OL DERIVATIVES USEFUL IN THE TREATMENT OF GPR81 RECEPTOR DISORDERS<br/>[FR] DÉRIVÉS 3H-IMIDAZO[4,5-B]PYRIDIN-5-OL UTILES DANS LE TRAITEMENT DE TROUBLES DU RÉCEPTEUR GPR81
  申请人：ARENA PHARM INC

  公开号：WO2010030360A1

  公开（公告）日：2010-03-18

  The present invention is directed to certain 3H-imidazo[4,5-b]pyridin-5-ol derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the GPR81 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of GPR81 associated disorders, for example, dyslipidemia, atherosclerosis, atheromatous disease, hypertension, coronary heart disease, stroke, insulin resistance, impaired glucose tolerance, type 2 diabetes, syndrome X, obesity, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes and acne.

  本发明涉及某些Formula（Ia）的3H-咪唑[4,5-b]吡啶-5-醇衍生物及其药学上可接受的盐，这些衍生物具有有用的药理特性，例如作为GPR81受体的激动剂。本发明还提供了含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗GPR81相关疾病的方法，例如脂质代谢异常、动脉粥样硬化、动脉粥样病、高血压、冠心病、中风、胰岛素抵抗、糖耐量受损、2型糖尿病、X综合征、肥胖、牛皮癣、类风湿性关节炎、克罗恩病、移植排斥反应、多发性硬化症、全身性红斑狼疮、溃疡性结肠炎、1型糖尿病和痤疮。
• Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0003560A2

  公开（公告）日：1979-08-22

  Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, aryloxy, arylalkyloxy, arylhydroxymethylene, arylcarbonyl, arylalkylcarbonyl, alkyloxy, alkylthio or a substituted cycloalkyl or cycloalkenyl group or (ii) A is a -S02- group and R is aryl or heterocyclyl or (iii) A is a chemical bond and R is a heterocyclyl or substituted phenyl group, or (iv) A is an aliphatic hydrocarbon residue of from 1 to 3 carbon atoms and R is a halophenyl group. Some of these imidazoles and salts are novel. Methods of preparing the imidazoles are disclosed. The imidazoles and their salts are useful in the treatment or prophylaxis of thrombo-embolic conditions.

  药物制剂，包含式中的咪唑（或其药学上可接受的盐）： 其中 (i) A 是 1 至 4 个碳原子的脂族烃残基，R 是萘基、四氢萘基、杂环基、芳硫基、芳烷硫基、芳氧基、芳烷氧基、芳羟甲基、芳羰基、芳烷基羰基、烷氧基、烷硫基或取代的环烷基或环烯基，或 (ii) A 是-S02-基团，R 是芳基或杂环基，或 (iii) A 是化学键，R 是杂环基或取代苯基，或 (iv) A 是 1 至 3 个碳原子的脂肪烃残基，R 是卤代苯基。 其中一些咪唑和盐是新型的。 这些咪唑的制备方法已经公开。咪唑及其盐类可用于治疗或预防血栓栓塞。
• ADHESIVE COMPOSITION FOR SEMICONDUCTOR CIRCUIT CONNECTION AND ADHESIVE FILM CONTAINING THE SAME
  申请人：LG CHEM, LTD.

  公开号：US20210115021A1

  公开（公告）日：2021-04-22

  The present disclosure relates to a polymer compound having a specific structure, including an acrylic resin having a functional group capable of mutual hydrogen bonding with an acrylic resin having imidazole, a resin composition for bonding semiconductors including a thermoplastic resin; a thermosetting resin; a curing agent; and the polymer compound having a specific structure, and an adhesive film for semiconductor produced using the same.
• US4431815A
  申请人：——

  公开号：US4431815A

  公开（公告）日：1984-02-14